Introduction

Sleepiness is the main clinical expression of obstructive sleep apnea (OSA) syndrome resulting from upper airway collapse. Recent studies have discussed the fact that the presence of T. gondii cysts in the brain and the resulting biochemical and immunological mechanisms could be linked to neurobehavioral disorders. The aim of the present study was to explore the potential impact of chronic toxoplasmosis on sleepiness and on obstructive sleep apnea (OSA) severity in OSA obese patients.

Materials and methods

A case control study on obese patients screened for OSA was performed. According to the sleep disorder and matched based on gender, age and body mass index (BMI), two groups of obese patients were selected from our sample collection database. All patients were tested for toxoplasmosis serological status measuring anti-Toxoplasma IgG and IgM levels. Univariable and multivariable logistic regression models were performed to assess the impact of chronic toxoplasmosis on sleepiness and OSA severity.

Results

107 obese patients suffering from OSA were included in the study (median age: 53.3 years Interquartile range (IQR): [41.9–59.9]; median BMI: 39.4 kg/m² IQR: [35.5–44.1], apnea-hypopnea index = 27.5 events/h [10.7–49.9]). Chronic toxoplasmosis was present in 63.4% and 70.7% of patients with or without sleepiness (p = 0.48), respectively and was not associated either to sleepiness (OR: 0.76, 95% CI: [0.52; 2.33], p = 0.64) or OSA severity (OR = 1.75, 95% CI: [0.51; 5.98] p = 0.37).

Conclusion

Although chronic Toxoplasma infection in immunocompetent humans has been associated to several behavioral disorders or pathologies in recent literature, we demonstrate here that chronic toxoplasmosis is not associated to sleepiness and to sleep apnea syndrome severity in obese patients suspected of sleep apnea syndrome.

中文翻译：

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阻塞性睡眠呼吸暂停中的慢性弓形虫病和嗜睡是否存在联系？

介绍

嗜睡是上呼吸道塌陷导致的阻塞性睡眠呼吸暂停（OSA）综合征的主要临床表现。最近的研究讨论了T的存在这一事实。脑中的刚地囊肿及其产生的生化和免疫机制可能与神经行为异常有关。本研究的目的是探讨慢性弓形虫病对OSA肥胖患者的嗜睡和阻塞性睡眠呼吸暂停（OSA）严重程度的潜在影响。

材料和方法

进行了一项针对肥胖患者进行OSA筛查的病例对照研究。根据睡眠障碍并根据性别，年龄和体重指数（BMI）进行匹配，从我们的样本收集数据库中选择了两组肥胖患者。测试所有患者的弓形虫血清学状况，测量抗弓形虫IgG和IgM水平。进行单变量和多变量logistic回归模型来评估慢性弓形虫病对嗜睡和OSA严重程度的影响。

结果

研究纳入了107名患有OSA的肥胖患者（中位年龄：53.3岁四分位间距（IQR）：[41.9-59.9]； BMI中位数：39.4 kg / m ² IQR：[35.5-44.1]，呼吸暂停低通气指数= 27.5个事件/小时[10.7–49.9]）。慢性弓形虫病分别存在于有或没有嗜睡的患者中（分别为63.4％和70.7％）（p = 0.48），并且与嗜睡无关（OR：0.76，95％CI：[0.52; 2.33]，p = 0.64）或OSA严重程度（OR = 1.75，95％CI：[0.51; 5.98] p = 0.37）。

结论

尽管在最近的文献中，具有免疫能力的人的慢性弓形虫感染与几种行为失常或病理相关，但我们在此证明，在怀疑患有睡眠呼吸暂停综合症的肥胖患者中，慢性弓形虫病与嗜睡和睡眠呼吸暂停综合症的严重程度无关。