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Measurement of Chiral Molecular Parameters Based on a Combination of Surface Plasmon Resonance and Weak Value Amplification.
ACS Sensors ( IF 8.2 ) Pub Date : 2020-07-01 , DOI: 10.1021/acssensors.0c00346 Liping Xu 1, 2 , Lan Luo 3 , Hao Wu 2, 4 , Zhengchun Luo 1 , Zhiyou Zhang 3 , Haofei Shi 2 , Tianying Chang 1 , Peng Wu 2 , Chunlei Du 2 , Hong-Liang Cui 1, 2
ACS Sensors ( IF 8.2 ) Pub Date : 2020-07-01 , DOI: 10.1021/acssensors.0c00346 Liping Xu 1, 2 , Lan Luo 3 , Hao Wu 2, 4 , Zhengchun Luo 1 , Zhiyou Zhang 3 , Haofei Shi 2 , Tianying Chang 1 , Peng Wu 2 , Chunlei Du 2 , Hong-Liang Cui 1, 2
Affiliation
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A novel combination of surface plasmon resonance (SPR) and weak value amplification (WVA) is employed to measure the optical rotation angle and refractive index of chiral enantiomers such as sugars and amino acids. An extremely low optical rotation change (2.73 × 10–4 rad) is readily measurable, with a resolution of 6.75 × 10–7 rad, 1 order of magnitude higher than that obtained using weak value amplification with intensity modulation, and a refractive index change of 1.13 × 10–6 RIU is also detected, with a resolution of 1.99 × 10–9 RIU, a nearly 1-order-of-magnitude increase in sensitivity over weak measurement based on a Mach–Zehnder interferometer. The optical activity and refractive index changes of chiral molecules are determined in real time by measurements of the output light intensity variation, whereby the absolute configuration of the chiral molecule is identified through the relation between intensity and molecular orientation. The SPR–WVA combination sensing scheme fills the gap of capability for detecting the optical activity of a molecular solution, which has not been possible with conventional SPR alone.
中文翻译：
基于表面等离振子共振和弱值放大相结合的手性分子参数的测量。
表面等离子体激元共振（SPR）和弱值扩增（WVA）的新颖结合被用于测量手性对映异构体（如糖和氨基酸）的旋光角和折射率。旋光度变化极低（2.73×10 –4 rad）很容易测量，分辨率为6.75×10 –7 rad，比使用强度调制的弱值放大和折射率变化高1个数量级。还检测到1.13×10 –6 RIU的分辨率为1.99×10 –9RIU，基于Mach-Zehnder干涉仪的弱测量，灵敏度提高了近1个数量级。通过测量输出光强度变化来实时确定手性分子的光学活性和折射率变化，从而通过强度和分子取向之间的关系来确定手性分子的绝对构型。SPR-WVA组合传感方案填补了检测分子溶液光学活性的能力的空白，这是单独使用常规SPR不可能实现的。
更新日期：2020-08-28
中文翻译：
基于表面等离振子共振和弱值放大相结合的手性分子参数的测量。
表面等离子体激元共振（SPR）和弱值扩增（WVA）的新颖结合被用于测量手性对映异构体（如糖和氨基酸）的旋光角和折射率。旋光度变化极低（2.73×10 –4 rad）很容易测量，分辨率为6.75×10 –7 rad，比使用强度调制的弱值放大和折射率变化高1个数量级。还检测到1.13×10 –6 RIU的分辨率为1.99×10 –9RIU，基于Mach-Zehnder干涉仪的弱测量，灵敏度提高了近1个数量级。通过测量输出光强度变化来实时确定手性分子的光学活性和折射率变化，从而通过强度和分子取向之间的关系来确定手性分子的绝对构型。SPR-WVA组合传感方案填补了检测分子溶液光学活性的能力的空白，这是单独使用常规SPR不可能实现的。
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