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Nanopore and Nanoparticle Formation with Lipids Undergoing Polymorphic Phase Transitions.
ACS Nano ( IF 15.8 ) Pub Date : 2020-07-01 , DOI: 10.1021/acsnano.0c02946 Diana Cholakova 1 , Desislava Glushkova 1 , Slavka Tcholakova 1 , Nikolai Denkov 1
ACS Nano ( IF 15.8 ) Pub Date : 2020-07-01 , DOI: 10.1021/acsnano.0c02946 Diana Cholakova 1 , Desislava Glushkova 1 , Slavka Tcholakova 1 , Nikolai Denkov 1
Affiliation
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We describe several unexpected phenomena, caused by a solid–solid phase transition (gel-to-crystal) typical for all main classes of lipid substances: phospholipids, triglycerides, diglycerides, alkanes, etc. We discovered that this transition leads to spontaneous formation of a network of nanopores, spreading across the entire lipid structure. These nanopores are spontaneously impregnated (flooded) by water when appropriate surfactants are present, thus fracturing the lipid structure at a nanoscale. As a result, spontaneous disintegration of the lipid into nanoparticles or formation of double emulsions is observed, just by cooling and heating of an initial coarse lipid-in-water dispersion around the lipid melting temperature. The process of nanoparticle formation is effective even after incorporation of medical drugs of high load, up to 50% in the lipid phase. The role of the main governing factors is clarified, the procedure is optimized, and the possibility for its scaling-up to industrially relevant amounts is demonstrated.
中文翻译：
纳米孔和纳米粒子与脂质经历多态相变的形成。
我们描述了几种意外的现象，这些现象是由所有主要类别的脂质物质的典型固-固相变（凝胶到晶体）引起的：磷脂，甘油三酸酯，甘油二酸酯，烷烃等。我们发现，这种转变导致纳米孔网络的自发形成，并遍布整个脂质结构。当存在适当的表面活性剂时，这些纳米孔会被水自然浸渍（淹没），从而使脂质结构在纳米级破裂。结果，仅通过在脂质熔化温度附近冷却和加热初始的粗的水包脂质分散体，观察到脂质自发崩解成纳米颗粒或形成双重乳液。即使在脂质相中掺入高达50％的高载量药物之后，纳米颗粒的形成过程仍然有效。阐明了主要控制因素的作用，优化了程序，并证明了将其扩大到与工业相关的量的可能性。
更新日期：2020-07-28
中文翻译：
纳米孔和纳米粒子与脂质经历多态相变的形成。
我们描述了几种意外的现象，这些现象是由所有主要类别的脂质物质的典型固-固相变（凝胶到晶体）引起的：磷脂，甘油三酸酯，甘油二酸酯，烷烃等。我们发现，这种转变导致纳米孔网络的自发形成，并遍布整个脂质结构。当存在适当的表面活性剂时，这些纳米孔会被水自然浸渍（淹没），从而使脂质结构在纳米级破裂。结果，仅通过在脂质熔化温度附近冷却和加热初始的粗的水包脂质分散体，观察到脂质自发崩解成纳米颗粒或形成双重乳液。即使在脂质相中掺入高达50％的高载量药物之后，纳米颗粒的形成过程仍然有效。阐明了主要控制因素的作用，优化了程序，并证明了将其扩大到与工业相关的量的可能性。
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