Most amino acids are encoded by multiple synonymous codons, some of which are used more rarely than others. Analyses of positions of such rare codons in protein sequences revealed that rare codons can impact co-translational protein folding and that positions of some rare codons are evolutionarily conserved. Analyses of their positions in protein 3-dimensional structures, which are richer in biochemical information than sequences alone, might further explain the role of rare codons in protein folding.

中文翻译：

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同义词密码子使用情况的网络分析。

大多数氨基酸由多个同义密码子编码，其中一些比其他密码子很少使用。此类稀有密码子在蛋白质序列中的位置分析表明，稀有密码子可影响共翻译蛋白折叠，并且某些稀有密码子的位置在进化上是保守的。分析它们在蛋白质3维结构中的位置，这些3D结构在生化信息上比单独的序列丰富，可能进一步解释了稀有密码子在蛋白质折叠中的作用。