Single protein imaging and understanding their interactions are of paramount importance to understand the life phenomena. Recently reported multiplex protein SIMS imaging methodology using metal-oxide nanoparticle conjugated antibodies can be extended to a single protein imaging methodology using He ion microscopy (HIM). It is proposed here that single protein can be imaged in the microscale and the nanoscale by the complementary use of SIMS and HIM.

中文翻译：

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通过SIMS和氦离子显微镜对蛋白质进行显微和纳米成像。

单一蛋白质成像和了解它们之间的相互作用对于了解生命现象至关重要。最近报道的使用金属氧化物纳米颗粒偶联抗体的多重蛋白质SIMS成像方法可以扩展到使用He离子显微镜（HIM）的单一蛋白质成像方法。在此建议，通过互补使用SIMS和HIM，可以在微米级和纳米级对单个蛋白质成像。