Cystic fibrosis (CF) is one of the most common autosomal recessive life-limiting conditions affecting Caucasians. The resulting defect in the cystic fibrosis transmembrane conductance regulator protein (CFTR) results in defective chloride and bicarbonate secretion, as well as dysregulation of epithelial sodium channels (ENaC). These changes bring about defective mucociliary clearance, reduced airway surface liquid and an exaggerated proinflammatory response driven, in part, by infection. In this short article we explore the overlap in the pathophysiology of CF and COVID-19 infection and discuss how understanding the interaction between both diseases may shed light on future treatments.

囊性纤维化（CF）是影响高加索人的最常见的常染色体隐性寿命限制疾病之一。囊性纤维化跨膜电导调节蛋白（CFTR）中产生的缺陷导致有缺陷的氯化物和碳酸氢盐分泌，以及上皮钠通道（ENaC）失调。这些改变导致粘膜纤毛清除不良，气道表面液减少以及部分受感染驱动的夸大的促炎反应。在这篇简短的文章中，我们探讨了CF和COVID-19感染的病理生理学重叠之处，并讨论了如何理解这两种疾病之间的相互作用可能为将来的治疗方法提供启示。