Abstract

Circadian rhythms affect a variety of physiological processes. Disruption of circadian rhythms causes many diseases, most of which are associated with inflammation. Disruption of circadian rhythms has a detrimental impact on the function of immune system. It is common to find that circulatory LPS are increased. LPS induces immune cells to produce inflammatory cytokines. Inflammatory cytokines play a role in skeletal muscle decay. Rev-erbβ has been identified as a critical regulator of circadian rhythms and a factor in inflammation. Another effect of disruption is a concomitant disturbance of glucose–insulin metabolism, which skeletal muscle likely contributes to considering it is a key metabolic tissue. Disruption of circadian rhythms is also related to obesity. Obesity can cause an increase expression of inflammatory cytokines. Maybe obesity with skeletal muscle decay is one of major characteristics. Future studies are needed to obtain a comprehensive understanding of inflammatory cytokines and skeletal muscle decay from the viewpoint of circadian rhythms.

摘要

昼夜节律影响多种生理过程。昼夜节律的破坏会导致许多疾病，其中大多数与炎症有关。昼夜节律的破坏对免疫系统的功能产生不利影响。通常会发现循环 LPS 增加。LPS 诱导免疫细胞产生炎性细胞因子。炎性细胞因子在骨骼肌衰退中起作用。Rev-erbβ 已被确定为昼夜节律的关键调节因子和炎症因子。破坏的另一个影响是伴随的葡萄糖-胰岛素代谢紊乱，骨骼肌可能有助于将其视为关键的代谢组织。昼夜节律的紊乱也与肥胖有关。肥胖会导致炎症细胞因子的表达增加。也许骨骼肌衰退的肥胖是主要特征之一。未来的研究需要从昼夜节律的角度全面了解炎症细胞因子和骨骼肌衰退。