Abstract

Objective

The aim of the present study was to evaluate oxidative stress state in non-alcoholic fatty liver (NAFLD) patients at the time of diagnosis and by passing three months from the treatment.

Methods

37 patients with NAFLD in summer 2019 were enrolled in this study. Also, 37 healthy controls that were matched for sex and age were included as a control group. Oxidative stress parameters such as lipid peroxidation (MDA), total antioxidant capacity (TAC), and Thiols were measured by standard methods and were then compared with before treatment.

Results

At the time of diagnosis, MDA levels were significantly increased and FRAP and Thiol levels were significantly decreased. After 3 months of treatment with pioglitazone, MDA levels decreased and FRAP and Thiol group increased.

Conclusions

Non-alcoholic fatty liver disease is associated with the higher levels of MDA and lower serum levels of total antioxidant capacity and Thiol group levels.

中文翻译：

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吡格列酮治疗后非酒精性脂肪肝患者硫醇基团和总抗氧化能力的改善

摘要

客观的

本研究的目的是评估非酒精性脂肪肝 (NAFLD) 患者在诊断时和治疗后三个月内的氧化应激状态。

方法

2019 年夏季 37 名 NAFLD 患者参加了这项研究。此外，还包括 37 名性别和年龄相匹配的健康对照作为对照组。通过标准方法测量氧化应激参数，如脂质过氧化（MDA）、总抗氧化能力（TAC）和硫醇，然后与治疗前进行比较。

结果

诊断时，MDA水平显着升高，FRAP和硫醇水平显着降低。吡格列酮治疗3个月后，MDA水平下降，FRAP和硫醇组升高。

结论

非酒精性脂肪肝与较高水平的 MDA 和较低的血清总抗氧化能力和硫醇基水平有关。