Abstract

Background

The Jat Sikh population is the largest endogamous group of Punjab, a state in north-west India, and has not yet been explored for genetic polymorphism based on X-STR genetic markers. In India, which is the second most populous country in the world, only two population studies based on X-STR markers have been reported so far.

Aim

To explore the genetic diversity of 12 X chromosomal STR genetic markers in the Jat Sikh population of Punjab and expand the X-STR polymorphism database.

Subjects and methods

In this study, a total of 200 Jat Sikh individuals (100 males and 100 females) residing in Punjab were investigated for 12 X-STR markers using the Investigator Argus X-12 QS Kit.

Results

The highest power of discrimination (PD) in females (PD_f) and males (PD_m) was observed to be 0.965 (DXS10135) and 0.929 (DXS10135 and DXS10148), respectively. DXS10135 was found to be the most polymorphic and discriminating locus among all the studied loci in both males and females with highest values of power of discrimination (PD) and polymorphic information content (PIC) as well.

Conclusion

Overall, the studied markers of the Argus 12 X-STR kit provide high polymorphic information which may prove to be an important tool in resolving issues such as missing person identification, incest, immigration disputes, kinship analysis and genealogical studies. The dataset obtained from this study will add to the present database of X-STRs.

中文翻译：

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印度旁遮普邦Jat Sikh人群X-STR标记的遗传多样性及其与全球39个人群的比较。

摘要

背景

Jat Sikh种群是印度西北部旁遮普邦最大的内婚群体，尚未针对基于X-STR遗传标记的遗传多态性进行研究。在印度这个世界上人口第二大的国家，到目前为止，只有两项基于X-STR标记的人口研究报告。

目标

为了探索旁遮普邦Jat Sikh人群中12个X染色体STR遗传标记的遗传多样性，并扩展X-STR多态性数据库。

主题与方法

在这项研究中，使用调查员Argus X-12 QS试剂盒调查了居住在旁遮普邦的200名Jat Sikh个体（100名男性和100名女性）中的12个X-STR标记。

结果

女性（PD _f）和男性（PD _m）的最高辨别力（PD）分别为0.965（DXS10135）和0.929（DXS10135和DXS10148）。在所有研究的基因座中，DXS10135是男性和女性中所有多态性和区分性最高的基因座，其鉴别力（PD）和多态性信息含量（PIC）的值也最高。

结论

总体而言，Argus 12 X-STR试剂盒的研究标记物提供了高度多态的信息，这可能被证明是解决诸如失踪人员识别，乱伦，移民纠纷，血缘关系分析和家谱研究等问题的重要工具。从这项研究中获得的数据集将添加到X-STR的现有数据库中。