Abstract

Macrophages (Mø) are immune cells with natural phagocytic ability and play an important role in tumorigenesis, development and metastasis. Mø play a dual role of tumour inhibition and tumour promotion in tumour development due to their two different phenotypes. Mø in the tumour microenvironment have long been referred to as tumour-associated Mø (TAMs). Mø are mainly involved in tumour resistance, cancer metastasis and mediating immunosuppression. Nowadays, Mø and Mø membranes have been widely used in drug delivery systems (DDSs) because of their good biocompatibility, natural phagocytosis and their important role in tumour development. In this review, from the perspective of Mø’s role in tumour development, we present strategies and drugs of Mø targeting and focusing on the several types of biomimetic nanoparticles constructed by Mø and Mø membranes in tumour therapy, and discuss the problem of this delivery system in present research and future directions.

摘要

巨噬细胞（Mø）是具有天然吞噬能力的免疫细胞，在肿瘤的发生、发展和转移中起重要作用。Mø由于其两种不同的表型在肿瘤发展中起到抑制肿瘤和促进肿瘤的双重作用。肿瘤微环境中的 Mø 长期以来被称为肿瘤相关 Mø (TAM)。Mø主要参与肿瘤抵抗、癌症转移和介导免疫抑制。如今，Mø 和 Mø 膜因其良好的生物相容性、自然吞噬作用及其在肿瘤发展中的重要作用而被广泛应用于药物递送系统（DDS）。在这篇综述中，从 Mø 在肿瘤发展中的作用来看，