Abstract

Three new compounds (methyl-3β,25-dihydroxycycloart-23-en-29-oate 3-sulfate (1), methyl-3β-hydroxy-25-methoxycycloart-23-en-29-oate 3-sulfate (2) and 3β-hydroxy-25-methoxycycloart-23-ene 3-sulfate (3)) and a known one (3β-hydroxycycloart-24-en-23-one 3-sulfate (4)) were isolated from Vietnamese red alga Tricleocarpa fragilis. All isolated compounds 1-4 showed potent inhibitory activity against yeast α-glucosidase with IC₅₀ values of 16.62 ± 2.80, 36.34 ± 4.04, 30.19 ± 5.01 and 6.52 ± 0.17 µM, respectively. The docking data showed that the substitutions at C-3 and the differences in the side chain of cycloartane-skeleton could influence the interaction of molecule with enzyme, which was consistent with the experimental findings.

摘要

三个新化合物 (methyl-3 β ,25-dihydroxycycloart-23-en-29-oate 3-sulfate ( 1 ),methyl-3 β -hydroxy-25-methoxycycloart-23-en-29-oate 3-sulfate ( 2) )和3β-羟基-25-甲氧基环芳烃-23-烯3-硫酸盐( 3 ))和一种已知的( 3β-羟基环芳烃-24-en-23-one 3-硫酸盐( 4 ))从越南红中分离出来藻类脆弱三叶草。所有分离的化合物1 - 4均显示出对酵母 α-葡萄糖苷酶的有效抑制活性，IC 为₅₀值分别为 16.62 ± 2.80、36.34 ± 4.04、30.19 ± 5.01 和 6.52 ± 0.17 µM。对接数据表明，C-3的取代和环阿烷骨架侧链的差异会影响分子与酶的相互作用，这与实验结果一致。