Abstract

Two new milbemycin derivatives, milbemycin M (1) and milbemycin N (2), were isolated from the culture of a genetically engineered strain Streptomyces bingchenggensis BCJ60. Their structures were elucidated through the interpretation of NMR and HR-ESI-MS spectroscopic data, as well as comparison with previous reports. The acaricidal and nematicidal activities of them against Tetranychus cinnabarinus and Bursaphelenchus xylophilus were tested. The results showed that compounds 1–2 possessed potent acaricidal and nematocidal activities.

中文翻译：

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两种新的米尔倍霉素衍生物来自基因工程菌株 Streptomyces bingchenggensis

摘要

两种新的米尔倍霉素衍生物米尔倍霉素 M ( 1 ) 和米尔倍霉素 N ( 2 ) 从基因工程菌株Streptomyces bingchenggensis BCJ60的培养物中分离出来。它们的结构是通过核磁共振和 HR-ESI-MS 光谱数据的解释以及与以前的报告进行比较来阐明的。测试了它们对朱砂叶螨和松材线虫的杀螨和杀线虫活性。结果表明，化合物1 - 2具有强效的杀螨和杀线虫活性。