Magnetic drug targeting (MDT) is a noninvasive method for the medical treatment of various diseases of the cardiovascular system. Biocompatible magnetic nanoparticles loaded with medicinal drugs are carried to a tissue target in the human body (in vivo) under the applied magnetic field. The present study examines the MDT technique in various microchannels geometries by adopting the principles of biofluid dynamics (BFD). The blood flow is considered as laminar, pulsatile and the blood as an incompressible and non-Newtonian fluid. A two-phase model is adopted to resolve the blood flow and the motion of magnetic nanoparticles (MNPs). The numerical results are obtained by utilizing a meshless point collocation method (MPCM) alongside with the moving least squares (MLS) approximation. The numerical results are verified by comparing with published numerical results. We investigate the effect of crucial parameters of MDT, including (1) the volume fraction of nanoparticles, (2) the location of the magnetic field, (3) the strength of the magnetic field and its gradient, (4) the way that MNPs approach the targeted area, and (5) the bifurcation angle of the vessel.

中文翻译：

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用于磁性药物靶向的两相生​​物流体流动模型

磁性药物靶向（MDT）是一种用于治疗心血管系统各种疾病的无创方法。在外加磁场下，载有药物的生物相容性磁性纳米粒子被携带到人体（体内）的组织目标。本研究采用生物流体动力学 (BFD) 原理，研究了各种微通道几何形状中的 MDT 技术。血流被认为是层流的、脉动的，而血液是不可压缩的非牛顿流体。采用两相模型来解决血流和磁性纳米粒子 (MNP) 的运动。数值结果是通过利用无网格点配置方法 (MPCM) 和移动最小二乘法 (MLS) 近似获得的。通过与已发表的数值结果进行比较来验证数值结果。我们研究了 MDT 关键参数的影响，包括 (1) 纳米粒子的体积分数，(2) 磁场的位置，(3) 磁场强度及其梯度，(4) MNPs 的方式接近目标区域，以及 (5) 血管的分叉角。