Supercritical carbon dioxide has been used to deposit co-precipitates of natural antioxidants with a polymer onto silica microparticles. The supercritical antisolvent process (SAS) was carried out with the antioxidants by introducing the silica microparticles into the precipitator vessel. Two different configurations were employed to pump the solution. In one configuration, the antioxidant and the polymer were dissolved and injected together through a nozzle. In the second configuration, the antioxidant and the polymer were dissolved in different solutions and sprayed through different nozzles. The use of operating conditions significantly above the critical point (180 bar and 323 K) led to the formation of composites made up of co-precipitates and silica. Delivery profiles showed that the presence of the polymer and the silica delayed release of the antioxidant into gastric media, thus protecting it and allowing its full delivery to the intestinal fluids to improve the effectiveness of the antioxidant.

中文翻译：

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使用超临界抗溶剂工艺在二氧化硅颗粒上沉积CAP /抗氧化剂系统

超临界二氧化碳已用于将天然抗氧化剂与聚合物的共沉淀物沉积到二氧化硅微粒上。通过将二氧化硅微粒引入沉淀池中，用抗氧化剂进行超临界抗溶剂工艺（SAS）。采用两种不同的配置来泵送溶液。在一种配置中，抗氧化剂和聚合物被溶解并通过喷嘴一起注入。在第二种配置中，抗氧化剂和聚合物溶解在不同的溶液中，并通过不同的喷嘴喷雾。使用明显高于临界点（180 bar和323 K）的操作条件导致形成了由共沉淀物和二氧化硅组成的复合材料。