In the present study, potential ameliorative effects of dietary ginger (GN) were investigated on antioxidant and immune responses of rainbow trout (Oncorhynchus mykiss) during oxytetracycline (OX) administration. As a 2 × 3 factorial design, the fish were orally treated with OX (a daily dose of 100 mg/kg) and GN (either 10 or 20 g/kg diet) for 10 days. Then, blood samples were taken from each treatment to monitor plasma lysozyme, complement (ACH50), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione‐S‐transferase (GST) activities, and reduced glutathione (GSH), malondialdehyde (MDA), total immunoglobulin (Ig) and globulin levels. OX treatment significantly decreased SOD (30%), GPx, (10%) and lysozyme (23%) activities, and GSH (19%) levels; however, it increased GST (16%) activity and MDA (28%) levels. Ten grams GN per kg levels significantly decreased SOD (35%), CAT (13%), GST (20%) and MDA (30%), but increased GSH (30%), lysozyme (48%) and globulin (16%). Twenty grams GN per kg diet significantly decreased SOD (26%) and MDA (17%), but increased lysozyme (31%) levels. Interaction effects of dietary GN and OX were observed on plasma MDA and GPx levels, as 10 g GN per kg diet prevented the OTC‐induced changes in these parameters. Moreover, 20 g GN per kg diet prevented the OX‐induced change in GPx activity and mitigated the MDA elevation by 20%. It is concluded that GN administration at 10 g/kg diet is beneficial in mitigating oxidative stress and immunosuppression of rainbow trout during OX administration.

中文翻译：

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饮食中的生姜可减轻虹鳟鱼中土霉素的氧化应激和免疫抑制（Oncorhynchus mykiss）

在本研究中，研究了饮食姜（GN）对虹鳟鱼（Oncorhynchus mykiss）的抗氧化和免疫反应的潜在改善作用。）在土霉素（OX）给药期间。作为2×3析因设计，将鱼用OX（每日剂量100 mg / kg）和GN（10或20 g / kg饮食）口服处理10天。然后，从每次治疗中抽取血样以监测血浆溶菌酶，补体（ACH50），超氧化物歧化酶（SOD），过氧化氢酶（CAT），谷胱甘肽过氧化物酶（GPx），谷胱甘肽S-转移酶（GST）活性和减少的谷胱甘肽（ GSH），丙二醛（MDA），总免疫球蛋白（Ig）和球蛋白水平。OX处理显着降低了SOD（30％），GPx（10％）和溶菌酶（23％）活性以及GSH（19％）的水平；但是，它增加了GST（16％）活性和MDA（28％）含量。每千克10克GN可以显着降低SOD（35％），CAT（13％），GST（20％）和MDA（30％），但增加GSH（30％），溶菌酶（48％）和球蛋白（16％） ）。每公斤日粮20克GN可显着降低SOD（26％）和MDA（17％），但增加溶菌酶（31％）水平。饮食中的GN和OX相互作用对血浆MDA和GPx水平产生了影响，因为每公斤饮食10 g GN可以阻止OTC引起的这些参数变化。此外，每公斤日粮20 g GN可以防止OX诱导的GPx活性变化，并使MDA升高降低20％。结论是，以10 g / kg的日粮进行GN施用有利于减轻OX施用期间虹鳟的氧化应激和免疫抑制。每公斤日粮20 g GN可防止OX诱导的GPx活性变化，并使MDA升高降低20％。结论是，以10 g / kg的日粮GN施用有利于减轻OX施用过程中虹鳟的氧化应激和免疫抑制。每公斤日粮20 g GN可防止OX诱导的GPx活性变化，并使MDA升高降低20％。结论是，以10 g / kg的日粮进行GN施用有利于减轻OX施用过程中虹鳟的氧化应激和免疫抑制。