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Synthesis and antimicrobial evaluation of the novel heteroannulated furo[3′,2′:6,7]chromeno[2,3‐b]pyridines: Part 1
Journal of Heterocyclic Chemistry ( IF 2.0 ) Pub Date : 2020-07-01 , DOI: 10.1002/jhet.4082 Magdy A. Ibrahim 1 , Sami A. Al‐Harbi 2 , Esam S. Allehyani 2
Journal of Heterocyclic Chemistry ( IF 2.0 ) Pub Date : 2020-07-01 , DOI: 10.1002/jhet.4082 Magdy A. Ibrahim 1 , Sami A. Al‐Harbi 2 , Esam S. Allehyani 2
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The chemical behavior of 4,9‐dimethoxy‐5‐oxo‐5H‐furo[3,2‐g]chromene‐6‐carbonitrile (1) was investigated toward some acyclic and cyclic active methylene ketones namely acetylacetone, ethyl acetoacetate, ethyl benzoylacetate, acetoacetanilide, dimedone, indanedione, pyrazolidine‐3,5‐dione and 5‐methyl‐2‐phenyl‐2,4‐dihydro‐3H‐pyrazol‐3‐one, barbituric acid and 1‐allylthiobarbituric acid, and hippuric acid. A variety of novel heteroannulated furochromenopyridines were efficiently synthesized through a cascade reactions between 4,9‐dimethoxy‐5‐oxo‐5H‐furo[3,2‐g]chromene‐6‐carbonitrile (1) and the carbon nucleophilic reagents. Structures of the new products were inferred based on their analytical and spectral data.
中文翻译：
新型杂环状呋喃并[3'，2'：6,7] chromeno [2,3-b]吡啶的合成与抗菌评价：第1部分
研究了4,9-二甲氧基-5-氧代-5 H-呋喃[3,2 - g ]亚甲基-6-腈（1）对一些无环和环状活性亚甲基酮的反应，即乙酰丙酮，乙酰乙酸乙酯，乙基苯甲酰乙酸，乙酰乙酰苯胺，二甲酮，茚二酮，吡唑烷-3-，5-二酮和5-甲基-2-苯基-2-，4-二氢-3 H-吡唑-3-酮，巴比妥酸和1-烯丙基硫代巴比妥酸和马尿酸。通过4,9-二甲氧基-5-氧代-5 H-呋喃[3,2 - g ]色烯-6-腈（1的级联反应）有效地合成了多种新型的异环呋喃铬吡啶）和碳亲核试剂。根据新产品的分析和光谱数据推断其结构。
更新日期：2020-07-01
中文翻译：
新型杂环状呋喃并[3'，2'：6,7] chromeno [2,3-b]吡啶的合成与抗菌评价：第1部分
研究了4,9-二甲氧基-5-氧代-5 H-呋喃[3,2 - g ]亚甲基-6-腈（1）对一些无环和环状活性亚甲基酮的反应，即乙酰丙酮，乙酰乙酸乙酯，乙基苯甲酰乙酸，乙酰乙酰苯胺，二甲酮，茚二酮，吡唑烷-3-，5-二酮和5-甲基-2-苯基-2-，4-二氢-3 H-吡唑-3-酮，巴比妥酸和1-烯丙基硫代巴比妥酸和马尿酸。通过4,9-二甲氧基-5-氧代-5 H-呋喃[3,2 - g ]色烯-6-腈（1的级联反应）有效地合成了多种新型的异环呋喃铬吡啶）和碳亲核试剂。根据新产品的分析和光谱数据推断其结构。
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