Synthesis, reactions, and antimicrobial activity of 2‐cyano‐N′‐(4‐(2‐oxo‐2‐phenylethoxy)benzylidene)acetohydrazide derivatives,Journal of Heterocyclic Chemistry

当前位置： X-MOL 学术 › J. Heterocycl. Chem. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Synthesis, reactions, and antimicrobial activity of 2‐cyano‐N′‐(4‐(2‐oxo‐2‐phenylethoxy)benzylidene)acetohydrazide derivatives
Journal of Heterocyclic Chemistry ( IF 2.0 ) Pub Date : 2020-07-01 , DOI: 10.1002/jhet.4084
Nadia Hanafy Metwally ₁ , Fathy Mohamed Abdelrazek ₁ , Salwa Magdy Eldaly ₁

Affiliation

Knӧvenagel condensation of the starting 2‐cyano‐N′‐(4‐(2‐oxo‐2‐phenylethoxy)‐benzylidene)acetohydrazide with different aromatic aldehydes produced the comparable arylidenes derivatives. Else way, 2‐cyano‐N′‐(4‐(2‐oxo‐2‐phenylethoxy)‐benzylidene)‐acetohydrazide condensed with o‐hydroxybenzaldehydes affording the respective chromenes which latter underwent acid hydrolysis giving the oxo‐chromenes analogues. Moreover, the reaction of 2‐cyano‐N′‐(4‐(2‐oxo‐2‐phenylethoxy)benzylidene)acetohydrazide with istain yielded the respective indeno[2,1‐b]furan derivative that was converted to its oxo‐analogue through acid hydrolysis. The treatment of 2‐cyano‐N′‐(4‐(2‐oxo‐2‐phenylethoxy)benzylidene)acetohydrazide with α‐halocompounds produced the relevant thiazoles. The enamine 2‐cyano‐3‐(dimethylamino)‐N′‐(4‐(2‐oxo‐2‐phenylethoxy)benzylidene)acrylohydrazide underwent nucleophilic substitution reaction with guanidine hydrochloride followed by heterocyclization to get the relative aminopyrimidine. Contrarily, the reaction with various 4‐arylazo‐3,5‐diaminopyrazoles provided the relative pyrazolo[1,5‐a]pyrimidines. The antimicrobial investigation was carried out for some of the newly synthesized compounds using agar well diffusion method.

中文翻译：

2-氰基-N'-（4-（2-氧代-2-苯基乙氧基）亚苄基）乙酰肼衍生物的合成，反应和抗菌活性

起始2-氰基-N ′-（4-（2-氧代-2-苯基乙氧基）-亚苄基）乙酰肼与不同芳族醛的Knvenagel缩合反应产生了可比的芳撑衍生物。否则，将2-氰基N '（4-（2-氧代-2-苯基乙氧基）-亚苄基）乙酰肼与邻羟基苯甲醛缩合，得到各自的色烯，后者经过酸水解得到氧代色烯类似物。此外，2-氰基-N '-（4-（2-氧代-2-苯基乙氧基）亚苄基）乙酰肼与istain的反应产生了相应的茚并[2,1- b ]呋喃衍生物，该衍生物被转化为其羰基-类似物通过酸水解。2-氰基氮的处理'（4-（2-氧代-2-苯基乙氧基）亚苄基）乙酰肼与α-卤代化合物产生了相关的噻唑。烯胺2-氰基-3-（二甲基氨基）N '-（4-（2-氧代-2-苯基乙氧基）亚苄基）丙烯酰肼与盐酸胍进行亲核取代反应，然后杂环化得到相对的氨基嘧啶。相反，与各种4-芳基偶氮-3,5-二氨基吡唑的反应提供了相对的吡唑并[1,5- a ]嘧啶。使用琼脂井扩散法对一些新合成的化合物进行了抗菌研究。

更新日期：2020-07-01

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11