One‐pot multicomponent synthesis and antimicrobial evaluation of novel tricyclic indenopyrimidine‐2‐amines,Journal of Heterocyclic Chemistry

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One‐pot multicomponent synthesis and antimicrobial evaluation of novel tricyclic indenopyrimidine‐2‐amines
Journal of Heterocyclic Chemistry ( IF 2.0 ) Pub Date : 2020-06-30 , DOI: 10.1002/jhet.4081
Navjot Kaur ₁ , Pratibha Singh ₁ , Pawandeep Kaur ₁ , Ajar Nath Yadav ₂ , Karan Singh ₁

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The synthesis of novel tricyclic indenopyrimidine‐2‐amines from 3,3‐dimethyl‐/3‐methyl‐2H‐indanones has achieved by base‐catalyzed one‐pot three‐component reaction. The desired products are formed within 10 hours after addition at reflux temperature. This multicomponent approach offers a viable protocol for the construction of indenopyrimidine‐2‐amines in single‐step without the isolation of the intermediates 3,3‐dimethyl/3‐methyl‐2‐(4‐substituted benzylidene)‐2,3‐dihydro‐1H‐inden‐1‐ones. All the synthesized compounds have been screened for antimicrobial activity and some of the derivatives show comparable activity against bacterial and fungal isolates.

中文翻译：

一锅多组分合成和新型三环茚并嘧啶-2-胺的抗菌性能评估

由3,3-二甲基/ 3-甲基-2 H-茚满酮合成新型三环茚并嘧啶-2-胺是通过碱催化一锅三组分反应实现的。加入后在回流温度下10小时内形成所需产物。这种多组分方法为一步一步制备茚并嘧啶-2-胺提供了可行的方案，而无需分离中间体3,3-二甲基/ 3-甲基-2-（4-取代的亚苄基）-2,3-二氢‐1 H ―隐含1-1。已对所有合成的化合物进行了抗菌活性筛选，某些衍生物对细菌和真菌的分离物表现出可比的活性。

更新日期：2020-06-30

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