Nanogels with selective intracellular reactivity for intracellular tracking and delivery.,Chemistry - A European Journal

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Nanogels with selective intracellular reactivity for intracellular tracking and delivery.
Chemistry - A European Journal ( IF 3.9 ) Pub Date : 2020-07-01 , DOI: 10.1002/chem.202001802
Guangyue Zu ₁ , Olga Mergel ₁ , Laís Ribovski ₁ , Reinier Bron ₁ , Inge S Zuhorn ₁ , Patrick van Rijn ₁

Affiliation

A multimodal approach for hydrogel‐based nanoparticles was developed to selectively allow molecular conjugated species to either be released inside the cell or remain connected to the polymer network. Using the intrinsic difference in reactivity between esters and amides, nanogels with an amide‐conjugated dye could be tracked intracellularly localizing next to the nucleus, while ester‐conjugation allowed for liberation of the molecular species from the hydrogel network inside the cell, enabling delivery throughout the cytoplasm. The release was a result of particle exposure to the intracellular environment. The conjugation approach and polymer network building rely on the same chemistry and provide a diverse range of possibilities to be used in nanomedicine and theranostic approaches.

中文翻译：

具有选择性细胞内反应性的纳米凝胶，用于细胞内跟踪和递送。

开发了一种基于水凝胶的纳米粒子的多模式方法，以选择性地允许分子共轭物质在细胞内释放或保持与聚合物网络的连接。利用酯和酰胺之间反应性的内在差异，可以在细胞内追踪具有酰胺共轭染料的纳米凝胶，定位在细胞核附近，而酯共轭允许从细胞内的水凝胶网络中释放分子物质，从而能够在整个过程中进行传递细胞质。该释放是颗粒暴露于细胞内环境的结果。缀合方法和聚合物网络构建依赖于相同的化学反应，并为纳米医学和治疗诊断方法提供了多种可能性。

更新日期：2020-07-01

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