Cooperative Catalysis of Copper, Silver, and Brønsted Acid for Three‐Component Carboamination of Arylalkenes with Allylic Alcohols and Nitriles,ChemCatChem

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Cooperative Catalysis of Copper, Silver, and Brønsted Acid for Three‐Component Carboamination of Arylalkenes with Allylic Alcohols and Nitriles
ChemCatChem ( IF 3.8 ) Pub Date : 2020-07-01 , DOI: 10.1002/cctc.202000842
Waqar Ahmed ₁ , Sheng Zhang ₁ , Xiujuan Feng ₁ , Xiaoqiang Yu ₁ , Yoshinori Yamamoto _{1,

2} , Ming Bao ₁

Affiliation

The cooperative catalysis of copper, silver, and Brønsted acid is presented as a new strategy for the intermolecular carboamination of arylalkenes. The catalytic regio‐ and chemoselective intermolecular carboamination of arylalkenes with allylic alcohols and nitriles provided a straightforward and efficient approach for preparing N‐acyl 4,5‐unsaturated amines. These amines can be used as synthetic organic synthons for the preparation of nitrogen‐containing five‐ and six‐membered heterocycles. During the functionalization reaction, synthetically useful functional groups, such as Cl, Br, and chloromethyl, remained intact.

中文翻译：

铜，银和布朗斯台德酸的协同催化用于烯醇与烯丙醇和腈的三组分碳氨化

铜，银和布朗斯台德酸的协同催化被提出为芳基烯烃分子间碳氨基化的新策略。芳基烯烃与烯丙醇和腈的催化区域和化学选择性分子间碳氨化为制备N-酰基4,5-不饱和胺提供了一种简单有效的方法。这些胺可用作合成有机合成子，用于制备含氮的五元和六元杂环。在官能化反应期间，合成上有用的官能团，例如Cl，Br和氯甲基，保持完整。

更新日期：2020-07-01

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