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Can Environmental Manipulation Help Suppress Cancer? Non-Linear Competition Among Tumor Cells in Periodically Changing Conditions.
Advanced Science ( IF 14.3 ) Pub Date : 2020-07-01 , DOI: 10.1002/advs.202000340
S G Babajanyan 1 , Eugene V Koonin 2 , Kang Hao Cheong 1
Affiliation  

It has been shown that the tumor population growth dynamics in a periodically varying environment can drastically differ from the one in a fixed environment. Thus, the environment of a tumor can potentially be manipulated to suppress cancer progression. Diverse evolutionary processes play vital roles in cancer progression and accordingly, understanding the interplay between these processes is essential in optimizing the treatment strategy. Somatic evolution and genetic instability result in intra‐tumor cell heterogeneity. Various models have been developed to analyze the interactions between different types of tumor cells. Here, models of density‐dependent interaction between different types of tumor cells under fast periodical environmental changes are examined. It is illustrated that tumor population densities, which vary on a slow time scale, are affected by fast environmental variations. Finally, the intriguing density‐dependent interactions in metastatic castration‐resistant prostate cancer (mCRPC) in which the different types of tumor cells are defined with respect to the production of and dependence on testosterone are discussed.

中文翻译:


环境调控可以帮助抑制癌症吗?周期性变化条件下肿瘤细胞之间的非线性竞争。



研究表明,周期性变化环境中的肿瘤群体生长动态可能与固定环境中的肿瘤群体生长动态截然不同。因此,可以通过操纵肿瘤的环境来抑制癌症的进展。不同的进化过程在癌症进展中发挥着至关重要的作用,因此,了解这些过程之间的相互作用对于优化治疗策略至关重要。体细胞进化和遗传不稳定性导致肿瘤细胞内的异质性。已经开发了各种模型来分析不同类型肿瘤细胞之间的相互作用。在这里,研究了快速周期性环境变化下不同类型肿瘤细胞之间密度依赖性相互作用的模型。结果表明,肿瘤群体密度在缓慢的时间尺度上变化,却受到快速环境变化的影响。最后,讨论了转移性去势抵抗性前列腺癌(mCRPC)中有趣的密度依赖性相互作用,其中不同类型的肿瘤细胞根据睾酮的产生和依赖性进行定义。
更新日期:2020-08-19
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