Artifact‐Free 2D Mapping of Neural Activity In Vivo through Transparent Gold Nanonetwork Array,Advanced Functional Materials

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Artifact‐Free 2D Mapping of Neural Activity In Vivo through Transparent Gold Nanonetwork Array
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2020-06-30 , DOI: 10.1002/adfm.202000896
Ji‐Won Seo _{1,

2} , Kiup Kim ₁ , Ki‐Won Seo ₁ , Mi Kyung Kim ₁ , Sohyeon Jeong _{3,

4} , Hyojung Kim ₁ , Jeong‐Wook Ghim ₅ , Jeong Ho Lee ₅ , Nakwon Choi _{3,

4,

6} , Jung‐Yong Lee ₁ , Hyunjoo J. Lee _{1,

7}

Affiliation

With the rapid increase in the use of optogenetics to investigate the nervous system, there is a high demand for a neural interface that enables 2D mapping of electrophysiological neural signals with high precision during simultaneous light stimulation. Here, a gold nanonetwork (Au NN)‐based transparent neural electrocorticogram (ECoG) monitoring system is proposed as implantable neural electronics. The neural interface enables accurate 2D mapping of ECoG neural signals without any photoelectric artifact during light stimulation. By using the Au NN, not only the transmittance of the microelectrodes is increased by 81% but also a low electrochemical impedance of 33.9 kΩ at 1 kHz with improved mechanical stability is achieved. It is demonstrated that the transparent microelectrode array records multichannel in vivo neural activities with no photoelectric artifact and a high signal‐to‐noise ratio. Propagation of neural dynamics of optically driven neural activities is also clearly visualized using the 2D Au NN microelectrode array. This transparent, flexible ECoG microelectrode array is a promising candidate for next‐generation in vitro and in vivo neural interface for 2D mapping of neural dynamics.

中文翻译：

通过透明金纳米网络阵列进行的神经活动体内无伪影的2D映射

随着光遗传学研究神经系统的迅速增加，对神经接口的需求很高，该神经接口能够在同时进行光刺激的同时高精度地对电生理神经信号进行二维映射。在此，提出了一种基于金纳米网络（Au NN）的透明神经电皮质图（ECoG）监视系统，作为可植入神经电子学。神经接口可在光刺激过程中对ECoG神经信号进行精确的2D映射，而无需任何光电伪像。通过使用Au NN，不仅微电极的透射率提高了81％，而且在1 kHz时实现了33.9kΩ的低电化学阻抗，并提高了机械稳定性。结果表明，透明微电极阵列记录了体内多通道神经活动，没有光电伪像，信噪比高。使用2D Au NN微电极阵列还可以清晰地看到光学驱动的神经活动的神经动力学的传播。这种透明，灵活的ECoG微电极阵列非常适合用于下一代体外和体内神经接口，用于神经动力学的二维映射。

更新日期：2020-08-19

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