Toward the New Generation of Surgical Meshes with 4D Response: Soft, Dynamic, and Adaptable,Advanced Functional Materials

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Toward the New Generation of Surgical Meshes with 4D Response: Soft, Dynamic, and Adaptable
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2020-06-30 , DOI: 10.1002/adfm.202004145
Sonia Lanzalaco _{1,

2} , Pau Turon ₃ , Christine Weis ₃ , Christian Mata ₁ , Eulàlia Planas ₁ , Carlos Alemán _{1,

2,

4} , Elaine Armelin _{1,

2}

Affiliation

Herein, a facile approach toward transforming a 2D polypropylene flexible mesh material into a 4D dynamic system is presented. The versatile platform, composed by a substrate of knitted fibers of isotactic polypropylene (iPP) mesh and a coating of thermosensitive poly(N‐isopropylacrylamide‐co‐N,N’‐methylene bis(acrylamide) (PNIPAAm‐co‐MBA) hydrogel, covalently bonded to the mesh surface, after cold‐plasma surface treatment and radical polymerization, is intended to undergo variations in its geometry via its reversible folding/unfolding behavior. The study is the first to trace the 3D movement of a flat surgical mesh, intended to repair hernia defects, under temperature and humidity control. An infrared thermographic camera and an optical microscope are used to evaluate the macroscopic and microscopic structure stimulus response. The presence of the PP substrate and the distribution of the gel surrounding the PP threads, affect both the PNIPAAM gel expansion/contraction as well as the time of folding/unfolding response. Furthermore, PP‐g‐PNIPAAm meshes show an increase in the bursting strength of ≈16% with respect to the uncoated mesh, offering a strongest and adaptable system for its future implantation in human body. The findings reported offer unprecedented application possibilities in the biomedical field.

中文翻译：

迈向具有4D响应的新一代外科手术网：柔软，动态和适应性强

在此，提出了一种将2D聚丙烯柔性网状材料转换为4D动态系统的简便方法。多功能平台，由等规聚丙烯（IPP）的针织纤维衬底组成的网格和热敏聚涂层（Ñ -isopropylacrylamide -共- N，N” -亚甲基双（丙烯酰胺）（PNIPAAm-共‐MBA）水凝胶，经过冷等离子体表面处理和自由基聚合后，共价键合到网状表面，旨在通过其可逆的折叠/展开行为使其几何形状发生变化。该研究是第一个在温度和湿度控制下追踪扁平手术网的3D运动的研究，旨在修复疝缺陷。红外热像仪和光学显微镜用于评估宏观和微观结构刺激响应。PP底物的存在以及PP线周围凝胶的分布会影响PNIPAAM凝胶的膨胀/收缩以及折叠/展开响应的时间。此外，PP- g‐PNIPAAm滤网相对于未涂覆的滤网，其爆裂强度提高了约16％，为将来的人体植入提供了最强大和适应性最强的系统。报告的发现为生物医学领域提供了前所未有的应用可能性。

更新日期：2020-09-03

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