当前位置: X-MOL 学术Trends Biotechnol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Emergence of the Stem Cell Secretome in Regenerative Engineering.
Trends in Biotechnology ( IF 14.3 ) Pub Date : 2020-07-01 , DOI: 10.1016/j.tibtech.2020.04.013
Leila Daneshmandi 1 , Shiv Shah 2 , Tahereh Jafari 3 , Maumita Bhattacharjee 3 , Deandra Momah 4 , Nikoo Saveh-Shemshaki 1 , Kevin W-H Lo 5 , Cato T Laurencin 6
Affiliation  

The secretome is defined as the set of molecules and biological factors that are secreted by cells into the extracellular space. In the past decade, secretome-based therapies have emerged as a promising approach to overcome the limitations associated with cell-based therapies for tissue and organ regeneration. Considering the growing number of recent publications related to secretome-based therapies, this review takes a step-by-step engineering approach to evaluate the role of the stem cell secretome in regenerative engineering. We discuss the functional benefits of the secretome, the techniques used to engineer the secretome and tailor its therapeutic effects, and the delivery systems and strategies that have been developed to use the secretome for tissue regeneration.



中文翻译:

再生工程中干细胞分泌组的出现。

分泌组被定义为由细胞分泌到细胞外空间的分子和生物因子的集合。在过去的十年中,基于分泌组的疗法已成为一种有前途的方法,可以克服与基于细胞的组织和器官再生疗法相关的局限性。考虑到最近与基于分泌组的疗法相关的出版物越来越多,本综述采用分步工程方法来评估干细胞分泌组在再生工程中的作用。我们讨论了分泌蛋白组的功能优势、用于设计分泌蛋白组并调整其治疗效果的技术,以及已开发的使用分泌蛋白组进行组织再生的递送系统和策略。

更新日期:2020-07-01
down
wechat
bug