Aspergillus fumigatus is a deadly fungal pathogen in immunocompromised patients. A report by Gonçalves et al. reveals that melanin, a secondary metabolite present at the surface of infecting fungal spores, induces glycolysis in macrophages to promote inflammatory responses. This opens a window for the development of innovative host-directed antifungal therapies.

中文翻译：

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真菌黑色素改变了巨噬细胞的代谢。

烟曲霉是免疫功能低下患者的致命真菌病原体。Gonçalves等人的报告。揭示黑色素是感染真菌孢子表面的次生代谢产物，可诱导巨噬细胞糖酵解，从而促进炎症反应。这为开发创新的针对宿主的抗真菌疗法开辟了一个窗口。