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Phase Separation of RNA Helicase Triggers Stress-Responsive Translational Switch.
Trends in Biochemical Sciences ( IF 11.6 ) Pub Date : 2020-07-01 , DOI: 10.1016/j.tibs.2020.06.008
Jogender Singh 1
Affiliation  

A swift response to stress requires global translational suppression, excepting stress proteins. Recently, Iserman et al. uncovered that stress-induced phase separation of the RNA helicase Ded1p results in translational suppression of housekeeping transcripts that contain complex 5′ untranslated regions (UTRs). Stress-response transcripts with simpler 5′ UTRs escape this global translational suppression.



中文翻译:

RNA解旋酶的相分离可触发应激反应性翻译开关。

对压力的快速反应需要整体翻译抑制,除了压力蛋白。最近,Iserman等人他们发现,应力诱导的RNA解旋酶Ded1p的相分离导致包含复杂的5'非翻译区(UTR)的管家转录本的翻译抑制。具有更简单的5'UTR的应激反应转录本摆脱了这种整体翻译抑制。

更新日期:2020-08-14
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