Four bench-scale sponge-based aerobic nitrifying moving bed biofilm reactors (MBBRs) were used to treat municipal wastewater containing typical pharmaceuticals (1 mg/L, 2 mg/L and 5 mg/L). This preliminary research aims to investigate the effects of sulfadiazine (SDZ), ibuprofen (IBU) and carbamazepine (CBZ) on nitrification performance and explore specific microbial diversity and functional gene (Ammonia-oxidizing bacteria (AOB), amoA) of MBBRs. After 90 days of operation, the MBBR without pharmaceuticals could remove up to 97.4 ± 1.5% of NH₄⁺-N while the removals of NH₄⁺-N by the MBBRs with SDZ, IBU and CBZ were all suppressed to varying degrees. Based on the Shannon and Chao 1 index, the specific microbial diversity and richness in biofilm samples increased at a range of 1 mg/L to 2 mg/L pharmaceuticals (SDZ, IBU or CBZ) and started decreasing after the pharmaceutical concentration was higher than 2 mg/L. The determination of functional gene (AOB amoA) showed that Proteobacteria was the most dominant bacteria within all biofilms with the relative abundance ranging from 24.81% to 55.32%. Furthermore, Nitrosomonas was the most numerous genus in AOB, followed by Campylobacter and Thauera, whose relative abundance shifted under the pressure of different pharmaceuticals.

四个基于台式海绵的好氧硝化移动床生物膜反应器（MBBR）用于处理含有典型药物（1 mg / L，2 mg / L和5 mg / L）的市政废水。这项初步研究旨在研究磺胺嘧啶（SDZ），布洛芬（IBU）和卡马西平（CBZ）对硝化性能的影响，并探索MBBRs的特定微生物多样性和功能基因（氨氧化细菌（AOB），amoA）。手术90天后，不带药物的MBBR最多可去除97.4±1.5％的NH ₄ ⁺ -N，而去除NH ₄ ⁺具有SDZ，IBU和CBZ的MBBR产生的-N均在不同程度上受到抑制。根据Shannon和Chao 1指数，生物膜样品中的特定微生物多样性和丰富度在1 mg / L至2 mg / L药物（SDZ，IBU或CBZ）的范围内增加，并且在药物浓度高于2毫克/升 功能基因（AOB amoA）的测定表明，变形杆菌是所有生物膜中最主要的细菌，相对丰度为24.81％至55.32％。此外，亚硝化单胞菌是AOB中最多的属，其次是弯曲杆菌属（Campylobacter）和丘拉属（Thauera），它们的相对丰度在不同药物的压力下发生了变化。