The development of precise neural circuits is initially directed by genetic programming and subsequently refined by neural activity. In the mouse olfactory system, axons from various olfactory sensory neurons expressing the same olfactory receptor converge onto a few spatially invariant glomeruli, generating the olfactory glomerular map in the olfactory bulbs. Using the glomerular map formation as a model, this review summarizes the current understanding of mechanisms underlying topographic map development in the mouse olfactory system and highlights how neural activity instructs the map refinement process.

中文翻译：

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细胞类型特定的模式化神经活动指导小鼠嗅觉系统中的神经图形成

精确神经回路的发展最初由遗传编程指导，随后由神经活动加以完善。在小鼠嗅觉系统中，来自表达相同嗅觉受体的各种嗅觉感觉神经元的轴突会聚到一些空间不变的肾小球上，在嗅球中生成嗅觉肾小球图。使用肾小球图形成作为模型，这篇综述总结了目前对小鼠嗅觉系统地形图发展机制的理解，并强调了神经活动如何指导地图细化过程。