Conventional treatments of bone tumor involve removal followed by radiation and chemotherapeutic drugs that may have limitations and cause secondary damage. The development of functional filling biomaterial has led to a new strategy for tumor therapy. In this study, a novel therapeutic ion selenium doped mesoporous bioactive glasses (Se/MBG) nanospheres were successfully synthesized by a facile sol–gel technique using cetyl trimethyl ammonium bromide (CTAB) as the template, which had uniform spherical morphology (≈ 400 nm), high surface area (>400 m²/g) and mesopore volume (≈0.30 cm³/g). Results showed that hydroxyapatite formation ability and controllable doxorubicin (DOX) release and distinct degradation of Se/MBG nanospheres depended on the dose of Se⁴⁺. In vitro cell cultures showed that both Se/MBG and DOX-Se/MBG nanospheres had the culture time and dose dependent cytotoxicity to MG63 osteosarcoma cells. But DOX-Se/MBG nanospheres reduced the acute cytotoxicity to MG63 because of the co-operative effect of Se and DOX. Meanwhile, Se/MBG nanospheres were found to have selective cytotoxicity to cancer cells (MG63) and normal cells (MC3T3-E1), indicating that the prepared Se/MBG nanospheres had cell recognition function. These all note that the synthesized Se/MBG nanospheres can be used as a filling biomaterial for the bone tissue engineering.

骨肿瘤的常规治疗包括切除，然后进行放射治疗和化疗药物，这些药物可能有局限性并引起继发性损害。功能性填充生物材料的发展导致了一种新的肿瘤治疗策略。在这项研究中，以十六烷基三甲基溴化铵（CTAB）为模板，通过简便的溶胶-凝胶技术成功地合成了一种新型的离子掺杂硒介孔生物活性玻璃（Se / MBG）纳米球，其球形形态均匀（≈400 nm） ），高表面积（> 400 m ² / g）和中孔体积（≈0.30cm ³ / g）。结果表明，Se / MBG纳米球的羟磷灰石形成能力和可控阿霉素（DOX）的释放和明显降解取决于Se ⁴⁺的剂量。体外细胞培养表明，Se / MBG和DOX-Se / MBG纳米球均具有对MG63骨肉瘤细胞的培养时间和剂量依赖性细胞毒性。但是由于Se和DOX的协同作用，DOX-Se / MBG纳米球降低了对MG63的急性细胞毒性。同时，发现Se / MBG纳米球对癌细胞（MG63）和正常细胞（MC3T3-E1）具有选择性的细胞毒性，表明所制备的Se / MBG纳米球具有细胞识别功能。这些都说明合成的Se / MBG纳米球可用作骨组织工程的填充生物材料。