Abstract New binuclear N-heterocyclic carbene (NHC) salts and their silver complexes were synthesized and confirmed through multiple spectroscopic techniques and determined their stability in solution form. The synthesized bis Ag(I)-NHC complexes were tested In Vitro against three bacterial strains (Staphylococcus aureus and Staphylococcus pneumonia and Escherichia coli) to measure their antibacterial potential. The antibacterial activity of silver complexes was far better than their respective ligands as well as standard drug silver sulfadiazine. The MIC value of silver complexes was almost in level to broad spectrum standard drug ciprofloxacin and very much better than silver sulfadiazine. The anticancer activity of silver complexes and their salts were measured in dose dependent response against HCT-116 which was in comparable to standard drug 5-Flourouracil. DNA affinity of complexes was found better than cisplatin and almost comparable with its analogue carboplatin.

中文翻译：

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芳基连接双核银N-杂环卡宾配合物的合成、DNA相互作用研究和生物学潜力

摘要 合成了新的双核N-杂环卡宾（NHC）盐及其银配合物，并通过多种光谱技术进行了确认，并确定了它们在溶液形式中的稳定性。合成的双银 (I)-NHC 复合物在体外针对三种细菌菌株（金黄色葡萄球菌、肺炎葡萄球菌和大肠杆菌）进行了测试，以测量它们的抗菌潜力。银配合物的抗菌活性远优于其各自的配体以及标准药物磺胺嘧啶银。银配合物的MIC值几乎与广谱标准药物环丙沙星相当，远优于磺胺嘧啶银。在对 HCT-116 的剂量依赖性反应中测量了银络合物及其盐的抗癌活性，这与标准药物 5-氟尿嘧啶相当。发现复合物的 DNA 亲和力优于顺铂，几乎与其类似物卡铂相当。