Neuroblastoma is the most frequent extracranial malignant solid tumor in children, and the 5 year OS of high risk neuroblastoma patients was less than 15%. This study aimed to identify biomarkers for risk stratification and prognosis prediction in neuroblastoma.149 low risk samples, 108 intermediate risk samples and 619 high risk samples were included in our study, and NBPF1 gene was found to be significantly correlated with risk levels and OS. Significant negative correlations between NBPF1 and the expression of MYCN and AKT1S1, and positive correlations between NBPF1 and KIF1B expression were found, but only NBPF1 was an independent biomarker based on the construct of PPI for MYCN, NBPF1, KIF1B and AKT1S1 by STRING enrichment.

神经母细胞瘤是儿童最常见的颅外恶性实体肿瘤，高危神经母细胞瘤患者的5年OS低于15%。本研究旨在确定神经母细胞瘤风险分层和预后预测的生物标志物。我们的研究包括149个低风险样本、108个中风险样本和619个高风险样本，发现NBPF1基因与风险水平和OS显着相关。发现NBPF1与MYCN和AKT1S1的表达呈显着负相关，NBPF1和KIF1B的表达呈正相关，但仅NBPF1是基于通过STRING富集构建MYCN、NBPF1、KIF1B和AKT1S1的PPI构建的独立生物标志物。