Current Opinion in Structural Biology ( IF 6.1 ) Pub Date : 2020-06-30 , DOI: 10.1016/j.sbi.2020.05.012 Hannes Ludewig 1 , Samuel Molyneux 1 , Scarlet Ferrinho 1 , Kai Guo 1 , Rosemary Lynch 1 , Danai S Gkotsi 1 , Rebecca Jm Goss 1
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Over 5000 halogenated natural products have been reported so far, many of these arising from the marine environment. The introduction of a halogen into a molecule can significantly impact its bioavailability and bioactivity. More recently enzymatic halogenation has been used to enable late stage functionalisation through site-selective halogenation and cross-coupling. Halogenases are becoming increasingly valued tools. This review outlines the various classes of halogenases that have been discovered, and examines these from both a structural and a mechanistic perspective, reflecting upon the many recent advances in halogenase discovery.
中文翻译：
卤化酶：结构和功能。
迄今为止，已报道了 5000 多种卤化天然产物，其中许多来自海洋环境。将卤素引入分子会显着影响其生物利用度和生物活性。最近，酶促卤化已被用于通过位点选择性卤化和交叉偶联实现后期功能化。卤化酶正成为越来越有价值的工具。这篇综述概述了已发现的各类卤化酶，并从结构和机制的角度对这些进行了研究，反映了卤化酶发现的许多最新进展。
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