The frequent detection of chloramphenicol (CAP) in wastewater and surface water gives rise to concerns on its fatal myelosuppression and aplastic anemia. Recently, the combination of ozone and peroxymonosulfate (O₃/PMS) has received wide attention in removing pollutants due to the multiple oxidants (i.e., O₃, hydroxyl radicals (OH) and sulfate radicals (SO₄⁻)) existed therein. This study showed that O₃/PMS could effectively degrade CAP under various conditions. The second-order rate constant of CAP with O₃, OH and SO₄⁻ was $0.291\pm 0.005$, $2.27(\pm 0.03)\times {10}^9$ and $1.02\left(\pm 0.02\right)\times {10}^8{M}^{-1}{s}^{-1}$, respectively. The degradation efficiency of CAP was significantly enhanced as PMS concentration or pH increased. Bicarbonate (HCO₃⁻) at concentration of 5 mM slightly inhibited CAP degradation at pH 7. Chloride (Cl⁻) at concentration of 0.5 mM enhanced CAP removal at pH 7, while this enhancement gradually weakened as Cl⁻ concentration further increased. The degradation efficiency of CAP first increased with increasing natural organic matter (NOM) concentrations (0.1–0.3 mg/L), while it was completely suppressed at higher NOM concentrations (0.5 mg/L). Four degradation products in total of CAP were identified in O₃-based processes (i.e., O₃, O₃/TBA, O₃/H₂O₂, O₃/PMS and O₃/PMS/tert-butyl alcohol (TBA) systems. Besides, these transformation products by OH, SO₄⁻ and/or O₃ were also distinguished. Finally, the impact of O₃/PMS pre-oxidation on the formation of dichloroacetamide (DCAcAm) from CAP during post-chlorination process was investigated. Compared with the traditional O₃ and O₃/H₂O₂ processes, O₃/PMS pre-oxidation generally led to the least generation of DCAcAm under similar conditions, where SO₄⁻ rather than OH was conducive to relieve the formation of DCAcAm. Moreover, the presence of NOM obviously alleviated the formation of DCAcAm by O₃/PMS pre-oxidation.

废水和地表水中氯霉素（CAP）的频繁检测引起人们对其致命性骨髓抑制和再生障碍性贫血的关注。最近，臭氧的组合和过氧单（O ₃ / PMS）已收到了广泛的关注在去除污染物由于多个氧化剂（即，O- ₃，羟自由基（OH）和硫酸根（SO ₄ ^- ））在其中存在。这项研究表明，O ₃ / PMS可以在各种条件下有效降解CAP。CAP的带O二阶速率常数₃，OH和SO ₄ ^-是$0.291\pm 0.005$， $2.27（\pm 0.03）\times {10}^9$ 和 $1.02\left(\pm 0.02\right)\times {10}^8{\mathrm{中号}}^{--\mathrm{1个}}{s}^{--\mathrm{1个}}$， 分别。随着PMS浓度或pH值的增加，CAP的降解效率显着提高。碳酸氢盐（HCO ₃ ^- ）在在pH 7氯化物（氯5mM的轻度抑制CAP降解的浓度^- ）为0.5mM的浓度增强在pH 7 CAP去除，而此增强逐渐减弱例如Cl ^-浓度进一步增加。CAP的降解效率首先随着天然有机物（NOM）浓度（0.1–0.3 mg / L）的增加而增加，而在较高的NOM浓度（0.5 mg / L）中被完全抑制。在基于O ₃的过程中总共鉴定出四种降解产物CAP （即O ₃，O ₃ / TBA，O ₃/ H ₂ O ₂，O ₃ / PMS和O ₃ / PMS /叔丁醇（TBA）系统。此外，这些转化产物由OH，SO ₄ ^-和/或O ₃也进行了区分。最后，研究了O ₃ / PMS预氧化对后氯化过程中CAP形成二氯乙酰胺（DCAcAm）的影响。与传统的相比ø ₃和O ₃ / H ₂ ö _2个过程，O- ₃ / PMS预氧化通常导致产生至少DCAcAm的相似的条件下，其中，SO ₄ ^-而不是OH有利于减轻DCAcAm的形成。此外，NOM的存在明显减轻了O ₃ / PMS预氧化对DCAcAm的形成。