Compared to conventional chemotherapy with subcutaneous and intravenous injection, injection of self-healing hydrogel drug-delivery system to tumor site brings less toxicity for normal tissues, but also better specificity for tumor cells on account of spontaneous repair and better retention. More importantly, it is essential to introduce multifunctional nanomaterials into self-healing hydrogel loading chemotherapeutic drugs to significantly enhance tumor treatment effect. Therefore, Rhodamin B isothiocyanate (RBITC)-labeled mesoporous silica nanospheres with Mn-Zn Ferrite (Mn_0.6Zn_0.4Fe₂O₄) nanoparticle core (MMSN-RBITC) are prepared and well-dispersed into hydrogel system. The generated heat under alternate magnetic field induces hyperthermia effect for magnetothermal therapy, which could also promote the sensibilization of chemotherapy. Hydroxyl radicals are produced via Fenton-like catalyzation after the cellular uptake of MMSN-RBITCs further promoting the cell apoptosis via chemodynamic therapy. The nanoplatform also presents excellent T₂-weighted magnetic resonance imaging contrast enhancement. As a result, the hydrogel system is effectively enhanced and enriched via the introduction of the nanospheres. In vitro and in vivo results indicate that this strategy of self-healing hydrogel loading DOX and MMSN-RBITC can achieve tumor diagnosis and efficiently synergistic magnetothermal-chemo-chemodynamic therapy. This strategy could inspire people to construct more promising platforms combining self-healing hydrogel with multifunctional nanomaterials for more efficient cancer treatment with versatile therapeutic methods.

与传统的皮下和静脉内注射化学疗法相比，向肿瘤部位注射自愈水凝胶药物递送系统对正常组织的毒性较小，但由于自发修复和保留效果更好，因此对肿瘤细胞的特异性更高。更重要的是，必须将多功能纳米材料引入自修复水凝胶负载化学治疗药物中，以显着增强肿瘤治疗效果。因此，用锰锌铁氧体（Mn _0.6 Zn _0.4 Fe ₂ O ₄）标记异硫氰酸罗丹明B（RBITC）介孔二氧化硅纳米球制备纳米粒子核（MMSN-RBITC）并充分分散到水凝胶体系中。交变磁场作用下产生的热量引起磁热疗法的热疗效果，也可能促进化学疗法的敏感性。MMSN-RBITCs被细胞吸收后，通过Fenton样催化产生羟基自由基，从而通过化学动力学疗法进一步促进细胞凋亡。纳米平台还具有出色的T ₂加权磁共振成像对比度增强功能。结果，通过引入纳米球有效地增强和丰富了水凝胶体系。体外和体内结果表明，这种自愈水凝胶加载DOX和MMSN-RBITC的策略可以实现肿瘤诊断并有效地进行磁热化学化学动力学协同治疗。该策略可能会激发人们构建更多有前途的平台，将自愈水凝胶与多功能纳米材料相结合，从而通过多种治疗方法更有效地治疗癌症。