Dearomatization is a fundamental chemical transformation, and it underlies some of the most efficient tactics for generating three-dimensional complexity from basic two-dimensional precursors. The dearomative toolbox, once restricted to only a handful of reactions, has begun to grow more sophisticated as novel methods are added, introducing more functionality under milder conditions and with more control over chemo-, regio-, and stereoselectivity than ever before. Over the past two decades, major developments in dearomative processes have bolstered significant total-synthesis endeavors and greatly expanded the scope and complexity of chemical building blocks accessible from feedstock arenes. In this Perspective, we highlight some of the recent advances and key challenges that remain in this vibrant area of organic chemistry.

脱芳构化是一种基本的化学转化，它是从基本二维前体生成三维复杂性的一些最有效策略的基础。脱芳香工具箱曾经仅限于少数反应，但随着新方法的添加，它已经开始变得更加复杂，在更温和的条件下引入更多功能，并且比以往更能控制化学、区域和立体选择性。在过去的二十年中，脱芳烃工艺的重大发展促进了全合成的重大进展，并极大地扩展了可从原料芳烃获得的化学结构单元的范围和复杂性。在本视角中，我们重点介绍了有机化学这一充满活力的领域的一些最新进展和仍然存在的关键挑战。