Although contact lenses are widely used for vision correction, they are also the primary cause of a number of ocular diseases such as microbial keratitis (MK), etc. and inflammatory events such as infiltrative keratitis (IK), contact lens acute red eye (CLARE), contact lens-induced peripheral ulcer (CLPU), etc. These diseases and infiltrative events often result from microbial contamination of lens care solutions and lens cases that can be exacerbated by unsanitary lens care and extended lens wear. The treatment of microbial biofilms (MBs) on lens cases and contact lenses are complicated and challenging due to their resistance to conventional antimicrobial lens care solutions. More importantly, MK caused by MBs can lead to acute visual damage or even vision impairment. Therefore, the development of lens cases, lens care solutions, and contact lenses with effective antimicrobial performance against MK will contribute to the safe use of contact lenses. This review article summarizes and discusses different chemical approaches for the development of antimicrobial contact lenses and lens cases employing passive surface modifications, antimicrobial peptides, free-radical fabricating agents, quorum sensing quenchers, antibiotics, antifungal drugs and various metals and coatings with antimicrobial nanomaterials. The benefits and shortcomings of these approaches are assessed, and alternative solutions for future developments are discussed.

尽管隐形眼镜已广泛用于视力矫正，但它们还是许多眼部疾病（例如微生物性角膜炎（MK）等）和炎症事件（例如浸润性角膜炎（IK），隐形眼镜急性红眼（CLARE）的主要原因，隐形眼镜诱发的周围性溃疡（CLPU）等。这些疾病和浸润事件通常是由镜片护理液和镜片盒的微生物污染引起的，而镜片卫生不佳和镜片长时间佩戴会加剧这种疾病。眼镜盒和隐形眼镜上的微生物膜的处理由于对常规抗菌眼镜护理液的抵抗力而变得复杂且具有挑战性。更重要的是，由MB引起的MK可能导致急性视力损害甚至视力损害。因此，开发眼镜盒，镜片护理解决方案，具有有效抗MK抗菌性能的隐形眼镜将有助于安全使用隐形眼镜。这篇综述性文章总结并讨论了使用被动表面改性，抗菌肽，自由基制造剂，群体感应淬灭剂，抗生素，抗真菌药物以及各种金属和带有抗菌纳米材料涂层的抗菌隐形眼镜和眼镜盒的开发方法。评估了这些方法的优点和缺点，并讨论了未来发展的替代解决方案。这篇综述性文章总结并讨论了使用被动表面改性，抗菌肽，自由基制造剂，群体感应淬灭剂，抗生素，抗真菌药物以及各种金属和带有抗菌纳米材料涂层的抗菌隐形眼镜和眼镜盒的开发方法。评估了这些方法的优点和缺点，并讨论了未来发展的替代解决方案。这篇综述性文章总结并讨论了使用被动表面改性，抗菌肽，自由基制造剂，群体感应淬灭剂，抗生素，抗真菌药物以及各种金属和带有抗菌纳米材料涂层的抗菌隐形眼镜和眼镜盒的开发方法。评估了这些方法的优点和缺点，并讨论了未来发展的替代解决方案。