Abstract

We studied the extraction and preconcentration of phenol and its hydroxy derivatives using individual and mixed micelles of nonionic and cationic surfactants with the digital recording of the analytical signal. This approach is based on the color reaction of phenols with diazotized 4-nitroaniline and micellar extraction of the products of their interaction (azo compound). The micellar extraction parameters (pH, the concentration of reagents, NaOH, and ethanol) were optimized for the efficient extraction of azo compounds of the studied phenols. The proposed method enables the determination of phenol and resorcinol at the MPC level with an error not exceeding 10%. For a qualitative assessment of the presence of phenols, the geometric parameters (area S, perimeter P) of the corresponding radar plots were used along with colorimetric parameters (R, G, B). The calibration dependences are linear within 1 × 10^–7–3 × 10^–5 M for phenol and 1 × 10^–7–2 × 10^–5 M for resorcinol and phloroglucinol. The developed colorimetric method was tested in the determination of resorcinol in the Rezortsinol pharmaceutical preparation.

中文翻译：

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胶束萃取预浓缩和比色法测定某些酚

摘要

我们使用非离子和阳离子表面活性剂的单独和混合胶束研究了苯酚及其羟基衍生物的提取和预富集，并对分析信号进行了数字记录。该方法基于酚与重氮化的4-硝基苯胺的显色反应，以及它们相互作用的产物（偶氮化合物）的胶束萃取。优化了胶束萃取参数（pH，试剂浓度，NaOH和乙醇），以有效萃取所研究酚类的偶氮化合物。所提出的方法能够在MPC水平上测定苯酚和间苯二酚，误差不超过10％。为了对酚的存在进行定性评估，应使用几何参数（面积S，周长P）和相应的比色参数（R，G，B）一起使用。苯酚的校准依赖性在1×10 ^–7 –3×10 ^–5 M内线性，间苯二酚和间苯三酚的校准依赖性在1×10 ^–7 –2×10 ^–5 M内。在确定Rezortsinol药物制剂中间苯二酚的含量时，对开发的比色法进行了测试。