Most mathematical modeling in biology relies either implicitly or explicitly on the epistemology of physics. The underlying conception is that the historicity of biological objects would not matter to understand a situation here and now, or, at least, historicity would not impact the method of modeling. We analyze that it is not the case with concrete examples. Historicity forces a conceptual reconfiguration where equations no longer play a central role. We argue that all observations depend on objects defined by their historical origin instead of their relations as in physics. Therefore, we propose that biological variations and historicity come first, and regularities are constraints with limited validity in biology. Their proper theoretical and empirical use requires specific rationales.

生物学中的大多数数学建模都隐含或明确地依赖于物理学认识论。基本概念是，生物对象的历史性对于理解此时此地的情况并不重要，或者至少，历史性不会影响建模方法。我们用具体的例子来分析，情况并非如此。历史性迫使方程式不再发挥核心作用的概念重新配置。我们认为所有的观察都依赖于由它们的历史起源定义的对象，而不是像物理学中的它们之间的关系。因此，我们建议首先考虑生物学变异和历史性，而规律性是生物学中有效性有限的约束。它们的正确理论和经验使用需要特定的理由。