Adenosine signaling has profound effects on sleep, many of which depend on the adenosine A 2A receptor (A 2A R). Here, we compared the sleep architecture of adult male A 2A R knockout ( A 2A R -KO) mice and wild-type littermates. While total time spent in each stage of wakefulness, non-rapid eye movement sleep (NREMS), and rapid eye movement sleep (REMS) was normal in A 2A R -KO mice, the episode durations of NREMS and REMS were reduced, suggesting that both stages are more fragmented. In addition, time spent in REMS during the light phase was increased. During NREMS, average delta power was reduced. These results provide insights into how congenital lack of A 2A Rs affects sleep.

中文翻译：

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腺苷 A2A 受体缺陷小鼠的睡眠结构

腺苷信号传导对睡眠有深远的影响，其中许多依赖于腺苷 A 2A 受体 (A 2A R)。在这里，我们比较了成年雄性 A 2A R 敲除 (A 2A R -KO) 小鼠和野生型同窝仔鼠的睡眠结构。虽然 A 2A R -KO 小鼠在觉醒、非快速眼动睡眠 (NREMS) 和快速眼动睡眠 (REMS) 的每个阶段花费的总时间是正常的，但 NREMS 和 REMS 的发作持续时间减少了，表明这两个阶段都更加分散。此外，在轻度阶段在 REMS 中花费的时间增加了。在 NREMS 期间，平均增量功率降低。这些结果提供了对先天性 A 2A Rs 缺乏如何影响睡眠的见解。