Mink enteritis virus (MEV) is a parvovirus that causes acute enteritis in mink. The capsid protein VP2 of MEV is a major immunogenicity that is important for disease prevention. In this study, this protein was expressed in Spodoptera frugiperda 9 cells using a recombinant baculovirus system and was observed to self-assemble into virus-like particles (VLPs) with a high hemagglutination (HA) titer (1:2¹⁶). A single-dose injection of VLPs (HA titer, 1:256) resulted in complete protection of mink against virulent MEV challenge for at least 180 days. These data suggest that these MEV VLPs could be used as a vaccine for the prevention of viral enteritis in mink.

貂水肠炎病毒（MEV）是一种细小病毒，可导致貂中的急性肠炎。MEV的衣壳蛋白VP2是主要的免疫原性，其对于疾病预防是重要的。在这项研究中，该蛋白使用重组杆状病毒系统在Spodoptera frugiperda 9细胞中表达，并被观察到自组装成具有高血凝（HA）效价（1：2 ¹⁶）的病毒样颗粒（VLP ）。VLP的单剂量注射（HA滴度，1：256）可在至少180天内完全保护貂皮免受强毒MEV攻击。这些数据表明，这些MEV VLP可用作疫苗预防貂的病毒性肠炎。