Pleurocorols A and B: rearranged steroids from the fruiting bodies of Pleurotus cornucopiae,Organic Chemistry Frontiers

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Pleurocorols A and B: rearranged steroids from the fruiting bodies of Pleurotus cornucopiae
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2020-06-30 , DOI: 10.1039/d0qo00605j
Takashi Kikuchi _{1,

2,

3} , Maki Mori _{1,

2,

3} , Yasuko In _{1,

2,

3} , Jie Zhang _{4,

5,

6,

7} , Takeshi Yamada _{1,

2,

3} , Tomoya Hirano _{1,

2,

3}

Affiliation

Pleurocorols A (1) and B (2) with unprecedented carbon skeletons were isolated from the fruiting bodies of Pleurotus cornucopiae. The structures of compounds 1 and 2 were determined by using spectroscopic data and X-ray crystallography as 11(9 → 8)abeo-ergostane and 5(6 → 7), 11(9 → 7)diabeo-ergostane steroids, respectively. Their inhibitory effect on nitric oxide production and their cytotoxic activity against cancer cell lines were evaluated.

中文翻译：

平菇A和B：从平菇平菇子实体中重新排列的类固醇

从平菇子实体中分离出具有空前碳骨架的平菇A（1）和B（2）。化合物的结构1和2是由如图11（9→8），使用的光谱数据和X射线晶体学确定的abeo- -ergostane和5（6→7），11（9→7）二ABEO分别-ergostane类固醇，。评价了它们对一氧化氮产生的抑制作用以及它们对癌细胞系的细胞毒活性。

更新日期：2020-07-28

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