Metallic complexes of macrocycles chelators 1,4,7-triazacyclononane-N,N,N-triacetic acid (NOTA) and 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) were synthetized with iron (III) giving Fe(III)-DOTA and Fe(III)-NOTA complexes. They were studied in comparison of ferricyanide and ferrocenemethanol on cyclic voltammetry with glassy carbon working electrode (GC) and screen-printed carbon electrode (SPCE). Diffusion coefficients and heterogeneous electron transfer rate constants were determined with Randles-Sevcik and Nicholson-Lavagnini methods. Using SPCE. The average values of diffusion coefficient and transfer rate constant were respectively of 1.34 × 10−6 cm2 s−1 and 1.01 × 10−3 cm s−1 for Fe(III)-DOTA, and 4.32 × 10−6 cm2 s−1 and 1.14 × 10−3 cm s−1 for Fe(III)-NOTA. Interestingly, characteristics of the synthetized complexes on SPCE compete advantageously with those of ferricyanide and ferrocenemethanol, making Fe(III)-DOTA and Fe(III)-NOTA potential markers for future biosensors development.

中文翻译：

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Fe(III)-DOTA/Fe(III)-NOTA 复合物：未来电化学生物传感器的有吸引力的替代标记

合成了大环螯合剂1,4,7-三氮杂环壬烷-N,N,N-三乙酸(NOTA)和1,4,7,10-四氮杂环十二烷-1,4,7,10-四乙酸(DOTA)的金属配合物铁 (III) 生成 Fe(III)-DOTA 和 Fe(III)-NOTA 复合物。在循环伏安法上使用玻璃碳工作电极 (GC) 和丝网印刷碳电极 (SPCE) 对铁氰化物和二茂铁甲醇进行比较研究。扩散系数和异质电子转移速率常数用 Randles-Sevcik 和 Nicholson-Lavagnini 方法确定。使用 SPCE。Fe(III)-DOTA 的扩散系数和传输速率常数的平均值分别为 1.34 × 10−6 cm2 s−1 和 1.01 × 10−3 cm s−1，以及 4.32 × 10−6 cm2 s−1 Fe(III)-NOTA 为 1.14 × 10−3 cm s−1。有趣的是，