Combined catechol-O-methyl-transferase-inhibition and Levodopa-Carbidopa intestinal gel (LCIG) infusion has the potential to reduce LCIG daily dose and the costs of this therapy. In this retrospective analysis, we report on Parkinson’s disease (PD) patients on LCIG with concomitant Opicapone. In 11patients, the introduction of Opicapone led to LCIG daily dose being reduced by 24.8% (p = 0.05)without any significant worsening of dyskinesia. Three patients withdrew from Opicapone due to side effects or inefficacy. LCIG daily dose reduction could lead to cost savings of £142,820.63/year in the United Kingdom while maintaining clinical care.

中文翻译：

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奥匹卡朋和左旋多巴-卡比多巴肠凝胶输注：医疗保健系统成本节约的出路？

联合儿茶酚-O-甲基转移酶抑制和左旋多巴-卡比多巴肠凝胶 (LCIG) 输注有可能减少 LCIG 的每日剂量和这种疗法的成本。在这项回顾性分析中，我们报告了使用 LCIG 并同时使用 Opicapone 的帕金森病 (PD) 患者。在 11 名患者中，Opicapone 的引入导致 LCIG 日剂量减少了 24.8% (p = 0.05)，而没有任何运动障碍的显着恶化。由于副作用或无效，三名患者退出了 Opicapone。在维持临床护理的同时，LCIG 每日剂量减少可以在英国节省 142,820.63 英镑/年的成本。