BACKGROUND:Thrombus formation and hemolysis are important factors in developing blood pumps and mechanical heart valve prostheses. These phenomena are induced by flow properties. High shear stress induces platelet and red cell damage. Computational fluid dynamics (CFD) analysis calculates shear stress of fluid and particle pathlines of blood cells. OBJECTIVE:We studied blood cell damage in a blood pump by using CFD analysis and proposed a method for estimating blood damage. METHODS:We analyzed a pulsatile blood pump that was developed as a totally implantable left ventricular assist system at Tokai University. Shear stress on blood cells throughout pulsatile blood pumps were analyzed using CFD software. RESULTS:Based on the assumption that the effect of shear stress on platelets is accumulated along the trace, we proposed a method for estimating blood damage using the damage parameter D. Platelet damage parameter is calculated regardless of the division time 𝛥t which is dependent on the calculation time step. The results of the simulations are in good agreement with Giersiepen’s equation obtained from the experiments. CONCLUSION:The history of shear stress on a particle was calculated using CFD analysis. The new damage parameter D yields a value close to that of Giersiepen’s equation with small errors.

中文翻译：

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使用计算流体动力学对血细胞进行剪应力评估。

背景：血栓形成和溶血是发展血泵和机械心脏瓣膜假体的重要因素。这些现象是由流动特性引起的。高剪切应力引起血小板和红细胞损伤。计算流体动力学（CFD）分析计算流体的切应力和血细胞的颗粒路径。目的：我们通过CFD分析研究了血泵中的血细胞损害，并提出了一种估计血损害的方法。方法：我们分析了东海大学开发为完全植入式左心室辅助系统的脉动血泵。使用CFD软件分析了整个脉动血泵对血细胞的剪切应力。结果：基于这样的假设：剪切应力对血小板的影响是沿着迹线累积的，我们提出了一种使用损伤参数D估算血液损伤的方法。血小板损伤参数的计算与划分时间𝛥t无关，后者取决于计算时间步长。仿真结果与实验获得的吉尔西彭方程很好地吻合。结论：利用CFD分析计算了颗粒上的剪切应力历史。新的损伤参数D产生的值接近Giersiepen方程的值，且误差很小。使用CFD分析计算颗粒上的剪切应力历史。新的损伤参数D产生的值接近Giersiepen方程的值，且误差很小。使用CFD分析计算颗粒上的剪切应力历史。新的损伤参数D产生的值接近Giersiepen方程的值，且误差很小。