Abstract: With continual rapid developments in the biomedical field and understanding of the important mechanisms and pharmacokinetics of biological molecules, controlled drug delivery systems (CDDSs) have been at the forefront over conventional drug delivery systems. Over the past several years, scientists have placed boundless energy and time into exploiting a wide variety of excipients, particularly diverse polymers, both natural and synthetic. More recently, the development of nano polymer blends has achieved noteworthy attention due to their amazing properties, such as biocompatibility, biodegradability and more importantly, their pivotal role in controlled and sustained drug release in vitro and in vivo. These compounds come with a number of effective benefits for improving problems of targeted or controlled drug and gene delivery systems; thus, they have been extensively used in medical and pharmaceutical applications. Additionally, they are quite attractive for wound dressings, textiles, tissue engineering, and biomedical prostheses. In this sense, some important and workable natural polymers (namely, chitosan (CS), starch and cellulose) and some applicable synthetic ones (such as poly-lactic-co-glycolic acid (PLGA), poly(lactic acid) (PLA) and poly-glycolic acid (PGA)) have played an indispensable role over the last two decades for their therapeutic effects owing to their appealing and renewable biological properties. According to our data, this is the first review article highlighting CDDSs composed of diverse natural and synthetic nano biopolymers, blended for biological purposes, mostly over the past five years; other reviews have just briefly mentioned the use of such blended polymers. We, additionally, try to make comparisons between various nano blending systems in terms of improved sustained and controlled drug release behavior.

Keywords: polymer blends, drug delivery, wound dressing, PLGA, chitosan, starch


中文翻译：

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用于改善受控药物释放的新兴聚合物纳米混合物：综述。


摘要：随着生物医学领域的不断快速发展以及对生物分子重要机制和药代动力学的认识，受控药物递送系统（CDDS）已处于传统药物递送系统的前沿。在过去的几年中，科学家们投入了无限的精力和时间来开发各种赋形剂，特别是天然和合成的多种聚合物。最近，纳米聚合物共混物的开发因其令人惊叹的特性而引起了人们的关注，例如生物相容性、生物降解性，更重要的是，它们在体外和体内的受控和持续药物释放中发挥着关键作用。这些化合物具有许多有效的益处，可改善靶向或受控药物和基因递送系统的问题；因此，它们已广泛用于医疗和制药应用。此外，它们对于伤口敷料、纺织品、组织工程和生物医学假体也非常有吸引力。从这个意义上讲，一些重要且可行的天然聚合物（即壳聚糖（CS）、淀粉和纤维素）和一些适用的合成聚合物（例如聚乳酸-乙醇酸（PLGA）、聚乳酸（PLA））和聚乙醇酸（PGA））由于其有吸引力的可再生生物特性，在过去二十年中在治疗效果方面发挥了不可或缺的作用。根据我们的数据，这是第一篇重点介绍由多种天然和合成纳米生物聚合物组成的 CDDS 的综述文章，这些聚合物为生物目的而混合，主要是在过去五年中；其他评论只是简单地提到了这种混合聚合物的使用。 此外，我们尝试在改善持续和受控药物释放行为方面对各种纳米混合系统进行比较。


关键词：聚合物共混物，药物递送，伤口敷料，PLGA，壳聚糖，淀粉