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Cytotoxic and Antimicrobial Efficacy of Silver Nanoparticles Synthesized Using a Traditional Phytoproduct, Asafoetida Gum.
International Journal of Nanomedicine ( IF 6.6 ) Pub Date : 2020-06-19 , DOI: 10.2147/ijn.s258319 Sandhanasamy Devanesan 1, 2 , Karuppiah Ponmurugan 3 , Mohamad S AlSalhi 1, 2 , Naif Abdullah Al-Dhabi 3
International Journal of Nanomedicine ( IF 6.6 ) Pub Date : 2020-06-19 , DOI: 10.2147/ijn.s258319 Sandhanasamy Devanesan 1, 2 , Karuppiah Ponmurugan 3 , Mohamad S AlSalhi 1, 2 , Naif Abdullah Al-Dhabi 3
Affiliation
Purpose: The present study synthesized silver nanoparticles (AgNPs) using the aqueous extract of a traditional medicinal product consisting of an oleoresin (a combination of macromolecules of carbohydrates and proteins) exuded from the rhizome of the plant Ferula foetida (asafoetida gum) and evaluated its biological properties.
Materials and Methods: The silver nanoparticles synthesized using asafoetida gum (As-AgNPs) were characterized using UV/Vis spectroscopy, fourier infrared (FTIR) spectroscopy, scanning electron microscopy (SEM) with energy dispersive X-ray analysis (EDX), X-ray diffraction (XRD) and transmission electron microscopy (TEM) and EADX. The cytotoxicity and antimicrobial activity As-AgNPs were evaluated against MCF-7 cell lines and selected microbial pathogens, respectively.
Results: The synthesized silver nanoparticles were crystalline in nature with a spherical shape. The average particle size was 5.6– 8.6 nm. The cytotoxicity of the synthesized As-AgNPs was evaluated against MCF-7 cell lines, and the As-AgNPs were found to be effective in inhibiting the multiplication of cancer cells. The As-AgNPs exhibited significant antimicrobial activity towards E. coli, K. pneumoniae and C. albicans. The MIC of the synthesized As-AgNPs was 7.80 μg/mL for E. coli ATCC 25922, Salmonella sp. WS50- and S. typhi; 15.60 μg/mL for S. typhimurium and S. aureus WS10, and 31.20 μg/mL for K. pneumoniae and S. aureus ATCC 43300-MRSA. In addition, MIC values of 15.60 μg/mL for C. albicans ATCC8436 and 31.20 μg/mL for C. krusei ATCC6258 were obtained.
Conclusion: As asafoetida is a good traditional medicine, its involvement in the synthesis of AgNPs led the silver nanoparticles to exhibit good cytotoxic and antimicrobial effects.
Keywords: asafoetida gum, AgNPs, antimicrobial, cytotoxicity, biomedical agent
中文翻译：
使用传统植物产品 Asafoetida Gum 合成的银纳米颗粒的细胞毒性和抗菌功效。
目的：本研究使用从植物阿魏（阿魏胶）的根茎中渗出的油树脂（碳水化合物和蛋白质的大分子组合）组成的传统医药产品的水提取物合成银纳米粒子（AgNPs），并评估其生物学特性。
材料和方法：使用阿魏胶合成的银纳米粒子 (As-AgNPs) 使用紫外/可见光谱、傅里叶红外 (FTIR) 光谱、扫描电子显微镜 (SEM) 与能量色散 X 射线分析 (EDX)、X 射线衍射 (XRD) 进行了表征) 和透射电子显微镜 (TEM) 和 EADX。分别针对 MCF-7 细胞系和选定的微生物病原体评估了 As-AgNPs 的细胞毒性和抗菌活性。
结果：合成的银纳米粒子本质上是结晶的，具有球形。平均粒径为 5.6–8.6 nm。合成的 As-AgNPs 对 MCF-7 细胞系的细胞毒性进行了评估，发现 As-AgNPs 可有效抑制癌细胞的增殖。As-AgNPs 对大肠杆菌、肺炎克雷伯菌和白色念珠菌表现出显着的抗菌活性。对于大肠杆菌ATCC 25922、沙门氏菌属，合成的 As-AgNPs 的 MIC 为 7.80 μg/mL 。WS50-和伤寒沙门氏菌；鼠伤寒沙门氏菌和金黄色葡萄球菌WS10为 15.60 μg/mL，肺炎克雷伯菌和金黄色葡萄球菌为 31.20 μg/mLATCC 43300-MRSA。此外，白色念珠菌ATCC8436 的 MIC 值为 15.60 μg/mL，克氏念珠菌ATCC6258 的MIC 值为31.20 μg/mL 。
结论：由于阿魏是一种优良的传统药物，其参与AgNPs的合成使银纳米粒子表现出良好的细胞毒和抗菌作用。
关键词：阿魏胶，AgNPs，抗菌素，细胞毒性，生物药剂
更新日期：2020-06-30
Materials and Methods: The silver nanoparticles synthesized using asafoetida gum (As-AgNPs) were characterized using UV/Vis spectroscopy, fourier infrared (FTIR) spectroscopy, scanning electron microscopy (SEM) with energy dispersive X-ray analysis (EDX), X-ray diffraction (XRD) and transmission electron microscopy (TEM) and EADX. The cytotoxicity and antimicrobial activity As-AgNPs were evaluated against MCF-7 cell lines and selected microbial pathogens, respectively.
Results: The synthesized silver nanoparticles were crystalline in nature with a spherical shape. The average particle size was 5.6– 8.6 nm. The cytotoxicity of the synthesized As-AgNPs was evaluated against MCF-7 cell lines, and the As-AgNPs were found to be effective in inhibiting the multiplication of cancer cells. The As-AgNPs exhibited significant antimicrobial activity towards E. coli, K. pneumoniae and C. albicans. The MIC of the synthesized As-AgNPs was 7.80 μg/mL for E. coli ATCC 25922, Salmonella sp. WS50- and S. typhi; 15.60 μg/mL for S. typhimurium and S. aureus WS10, and 31.20 μg/mL for K. pneumoniae and S. aureus ATCC 43300-MRSA. In addition, MIC values of 15.60 μg/mL for C. albicans ATCC8436 and 31.20 μg/mL for C. krusei ATCC6258 were obtained.
Conclusion: As asafoetida is a good traditional medicine, its involvement in the synthesis of AgNPs led the silver nanoparticles to exhibit good cytotoxic and antimicrobial effects.
Keywords: asafoetida gum, AgNPs, antimicrobial, cytotoxicity, biomedical agent
中文翻译：
使用传统植物产品 Asafoetida Gum 合成的银纳米颗粒的细胞毒性和抗菌功效。
目的：本研究使用从植物阿魏（阿魏胶）的根茎中渗出的油树脂（碳水化合物和蛋白质的大分子组合）组成的传统医药产品的水提取物合成银纳米粒子（AgNPs），并评估其生物学特性。
材料和方法：使用阿魏胶合成的银纳米粒子 (As-AgNPs) 使用紫外/可见光谱、傅里叶红外 (FTIR) 光谱、扫描电子显微镜 (SEM) 与能量色散 X 射线分析 (EDX)、X 射线衍射 (XRD) 进行了表征) 和透射电子显微镜 (TEM) 和 EADX。分别针对 MCF-7 细胞系和选定的微生物病原体评估了 As-AgNPs 的细胞毒性和抗菌活性。
结果：合成的银纳米粒子本质上是结晶的，具有球形。平均粒径为 5.6–8.6 nm。合成的 As-AgNPs 对 MCF-7 细胞系的细胞毒性进行了评估，发现 As-AgNPs 可有效抑制癌细胞的增殖。As-AgNPs 对大肠杆菌、肺炎克雷伯菌和白色念珠菌表现出显着的抗菌活性。对于大肠杆菌ATCC 25922、沙门氏菌属，合成的 As-AgNPs 的 MIC 为 7.80 μg/mL 。WS50-和伤寒沙门氏菌；鼠伤寒沙门氏菌和金黄色葡萄球菌WS10为 15.60 μg/mL，肺炎克雷伯菌和金黄色葡萄球菌为 31.20 μg/mLATCC 43300-MRSA。此外，白色念珠菌ATCC8436 的 MIC 值为 15.60 μg/mL，克氏念珠菌ATCC6258 的MIC 值为31.20 μg/mL 。
结论：由于阿魏是一种优良的传统药物，其参与AgNPs的合成使银纳米粒子表现出良好的细胞毒和抗菌作用。
关键词：阿魏胶，AgNPs，抗菌素，细胞毒性，生物药剂
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