Abstract: With the passage of time and more advanced societies, there is a greater emergence and incidence of disease and necessity for improved treatments. In this respect, nowadays, aptamers, with their better efficiency at diagnosing and treating diseases than antibodies, are at the center of attention. Here, in this review, we first investigate aptamer function in various fields (such as the detection and remedy of pathogens, modification of nanoparticles, antibiotic delivery and gene delivery). Then, we present aptamer-conjugated nanocomplexes as the main and efficient factor in gene delivery. Finally, we focus on the targeted co-delivery of genes and drugs by nanocomplexes, as a new exciting approach for cancer treatment in the decades ahead to meet our growing societal needs.

Keywords: aptamer, polyethyleneimine, hybrid nanocomplexes, antibiotic, targeting, gene delivery systems


中文翻译：

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适体混合纳米复合物作为抗生素/基因传递系统和诊断的靶向成分：综述。


摘要：随着时间的推移和社会的进步，疾病的出现和发病率越来越高，因此需要改进治疗方法。在这方面，当今，适配体因其比抗体更高效的诊断和治疗疾病而成为人们关注的焦点。在这篇综述中，我们首先研究适体在各个领域的功能（例如病原体的检测和治疗、纳米颗粒的修饰、抗生素递送和基因递送）。然后，我们将适配体缀合的纳米复合物作为基因传递的主要且有效的因素。最后，我们重点关注纳米复合物的基因和药物的靶向共同传递，作为未来几十年癌症治疗的一种令人兴奋的新方法，以满足我们不断增长的社会需求。


关键词：适体，聚乙烯亚胺，杂化纳米复合物，抗生素，靶向，基因传递系统