Chiral hydroxycarboxylates are useful compounds in the syntheses of natural products, pharmaceutical intermediates, and drugs. Here, we report on Zn- and Cu-containing sensors that can distinguish between enantiomers of hydroxycarboxylates through the quenching or the enhancement of fluorescence. A Zn-based sensor—[Zn^RRL]²⁺—is used in an assay to perform analyses of enantiomeric excess (% ee) of scalemic mixtures of α-hydroxycarboxylates and various drugs including the statin drug atorvastatin. This assay enables determination of mixtures of enantiomers across the range from 0 to 100% ee.

中文翻译：

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开发荧光锌（ii）和铜（ii）络合物，用于对映体过量测定羟基羧酸盐。

手性羟基羧酸盐在天然产物，药物中间体和药物的合成中是有用的化合物。在这里，我们报告了含锌和铜的传感器，它们可以通过猝灭或增强荧光来区分羟基羧酸盐的对映异构体。一种基于锌的传感器-[Zn ^RR L] 2 ⁺ -用于进行分析，以分析α-羟基羧酸盐与各种药物（包括他汀类药物阿托伐他汀）的鳞状混合物的对映体过量（％ee）。该测定法能够测定从0到100％ee范围内的对映体混合物。