COSAN-stabilised omega-3 oil-in-water nanoemulsions to prolong lung residence time for poorly water soluble drugs.,Chemical Communications

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COSAN-stabilised omega-3 oil-in-water nanoemulsions to prolong lung residence time for poorly water soluble drugs.
Chemical Communications ( IF 4.3 ) Pub Date : 2020-06-30 , DOI: 10.1039/d0cc00918k
Marcos Navascuez ₁ , Damien Dupin , Hans-Jürgen Grande , Vanessa Gómez-Vallejo , Iraida Loinaz , Unai Cossío , Jordi Llop

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Herein, we report on the capacity of the amphiphilic inorganic anion cobalt bis(dicarbollide) to stabilise oil-in-water nanoemulsions (NEs). The resulting NEs show long term stability in water and high drug-loading capacity, and can prolong the residence time of hydrophobic drugs in the lungs as determined by in vivo positron emission tomography imaging.

中文翻译：

COSAN稳定的omega-3水包油纳米乳剂可延长水溶性差的药物的肺停留时间。

在这里，我们报告了两亲性无机阴离子钴双（双糖脂）稳定水包油纳米乳液（NEs）的能力。通过体内正电子发射断层扫描成像确定，所得的NE在水中显示出长期稳定性并具有较高的载药量，并且可以延长疏水性药物在肺中的停留时间。

更新日期：2020-08-06

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