In the shoes industry, benzene constitute as one of the source of chemical hazard especially used in the gluing section. This compound is metabolized by the liver, forming free radicals in the body which can ultimately reduce the concentration of glutathione and increased malondialdehyde causing DNA degeneration. The purpose of this study was to determine the relationship between benzene concentration, excess cancer risk (ECR), malondialdehyde, glutathione, and DNA degeneration among workers in shoes industry in Osowilangun, Surabaya. This is an observational study with a cross-sectional design. The number of research samples was 25 respondents. The average concentration of benzene in workers was above the threshold (10.31 ppm). There were 15 (60%) respondents with ECR >0.0001 who experienced DNA degeneration. There was no relationship between benzene concentration, malondialdehyde, glutathione, and DNA degeneration. However, there was a relationship between benzene ECR, malondialdehyde, glutathione, and DNA degeneration in the shoe industry workers in Osowilangun.

在制鞋工业中，苯是化学危险源之一，尤其是在胶粘区使用。该化合物被肝脏代谢，在体内形成自由基，最终可以降低谷胱甘肽的浓度并增加丙二醛，从而导致DNA变性。这项研究的目的是确定泗水Osowilangun鞋业工人中苯浓度，超额癌症风险（ECR），丙二醛，谷胱甘肽和DNA变性之间的关系。这是一项具有横断面设计的观察性研究。研究样本数量为25名受访者。工人中苯的平均浓度高于阈值（10.31 ppm）。有15位（60％）ECR> 0.0001的受访者经历了DNA变性。苯浓度，丙二醛，谷胱甘肽和DNA变性之间没有关系。但是，奥索维兰贡的制鞋业工人中的苯ECR，丙二醛，谷胱甘肽和DNA退化之间存在关联。